Dicyclomine

Bentyl (Dicyclomine): Side Effects, Interactions, Warning, Dosage & Uses

What is Dicyclomine?

Contents

Dicyclomine is a Generic name for a drug that can help relax the smooth muscles of the gastrointestinal tract and thus helps to relieve the muscle spasm. It can present with a lot of anticholinergic side effects for that matter. Dicyclomine is  also known as Dicycloverine. This prescription drug is most commonly available on the market under the brand name Bentyl, and its main indication is treatment of irritable bowel syndrome – IBS. This drug is available in following formulations: tablet, capsule, or solution that should be taken by mouth in doses of 10 mg and 20 mg. It also comes as an solution for injection in doses of 10 mg/5ml, which should be only given by a healthcare provider and monitored in a clinic. Dicyclomine was discovered and first synthesized in 1947 in the United States of America by Wm S Merrell Company by the following process. FDA approved dicyclomine in 1950.

What is dicyclomine used for 20mg tablets?

Is Dicycloverine same as Dicyclomine?

Yes Dicycloverine is the same as Dicyclomine. Dicyclomine is the old name for it in the UK.

Is Dicyclomine an antibiotic?

According to the recent discoveries, it has announced that Dicyclomine being an antispasmodic has some antibacterial activity. It was tested in vivo and in-vitro. After doing experiments on animals it was confirmed that the drug can be given as an antibiotic as it has some antimicrobial potential in it.

What is Dicyclomine molecular formula and weight?

Dicyclomine molecular formula

Molecular formula:
C19H36ClNO2

It contains 19 atoms of carbon, 36 hydrogens, 1 chloride, 1 nitrogen and 2 oxygen

Molecular weight: 345.952 g/mol

Dicyclomine drug class

Chemically, dicyclomine belongs to the class of chemical entities known as carboxylic acid esters. These are carboxylic acid derivatives in which the carbon atom from the carbonyl group is attached to an alkyl or an aryl moiety through an oxygen atom (forming an ester group).

Pharmacologically, dicyclomine belongs to a class of drugs called anticholinergics. They have a special effect on acetylcholine.  Acetylcholine is a muscle contractor released by the nerves which help the muscles to contract. The effect of these anticholinergic drugs are mainly on the acetylcholine receptors which gets obstructed diminishing and decreasing the effect of the acetylcholine. When the acetylcholine is decreased it has a relaxing effect on the muscles.

How does Dicyclomine work in the body?

Dicyclomine is an anticholinergic drug, a drug that lowers the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle. It also has a direct effect of relaxation on smooth muscle. Dicyclomine is used to treat or prevent spasms in the muscles of the gastrointestinal tract in the irritable bowel syndrome. Moreover, Dicyclomine inhibits GIT propulsive motility and decreases secretion of gastric acid and controls excessive pharyngeal, tracheal and bronchial secretions. Action is achieved through a dual mechanism:

  • (1) a specific anticholinergic effect or antimuscarinic at the acetylcholine-receptor sites
  • (2) a direct effect upon smooth muscle – musculotropic

Dicyclomine brand names

The list of the brand names is huge as its manufactured by 342 companies and the list comprises of around 514 Brand names which are as follows:

Some of them are as follows:

  • Amigo
  • Acispasm
  • Bentyl
  • Canspas
  • Anti-Spa
  • Haspas
  • Ospas
  • Sysmol

What is Dicyclomine used for?

Dicyclomine being an antispasmodic helps relax the muscles of the digestive tract relieving any muscle spasm. Some of the Indications for this drug are:

  • Irritable bowel disease
  • Inflammation of Intestine
  • Muscle Cramps can also be relieved and pain can be managed in this way
  • Constipation can also be treated by this as its originally caused by the muscle spasm.

These conditions can be very painful and full of complications so using Dicyclomine can help manage these conditions very well.

Other uses also include reducing the muscle spasm of the urinary bladder and the following conditions/diseases might be helped or cured:

  • Colic
  • Bladder Spasm
  • Diarrhea
  • Spastic bowel
  • Diverticulosis

It is also sometimes used for the treatment of peptic ulcers as it reduces stomach acid to a small extent. It is rarely used in this as there are far better drugs available for these indications.

Dicyclomine use for irritable bowel disease

Yes, this drug  can be used for the irritable bowel disease since it is an anticholinergic or anti spasmodic drug. It basically helps relieve muscle spasm by inhibiting the release of acetylcholine which is a major muscle contractor.

Can Dicyclomine cause delirium?

Dicyclomine is a very beneficial drug for most of the patients but every good thing comes with something bad. It is reported that the females of age around 40-49 years and who have been taking Dicyclomine for more than 10 years complains of the side effect of delirium. These women were taking it with Xanax and had pain. It was confirmed that 5,885 people had such side effects while taking Bentyl from FDA.

Another study was conducted on 474 people who were taking Dicyclomine. Around 5 of them were reported to have the same side effect as well as of delirium.

Can Dicyclomine cause constipation?

One of the major side effects of Dicyclomine is constipation too and if someone has it so he should at once consult the doctor and get treated. It is due to the effect of this drug on intestinal motility which is reduced and thus constipation results. This needs to be sorted out. Sometimes it might go in a chronic stage and is accompanied by bloating and other symptoms like excessive gas or stomach cramps. For intensive constipation caused by this drug, patient is usually given stool softeners like docusate sodium. There are other stool softeners available as well which can be used for constipation. One other thing should be implemented by the patients having this problem is induction/incorporation of fibre supplements into their diet as well.

Can I take Dicyclomine if I have glaucoma?

This drug can be harmful to patients who have glaucoma and they should avoid taking it. The people who have glaucoma or taking medicine for it are contraindicated to take any form of Dicyclomine as this drug has a negative effect and interacts with the drugs they might be taking for glaucoma. So one should always consult your doctor if this problem arises or in this situation. Dicyclomine basically increases the pressure in the eyes and thus in glaucoma, this pressure is very harmful. You should always go to the doctor and ask for an alternative as this might solve one of your problems but might worsen your eye problem. You can’t surely take that for granted as eyes are one of the major organs. People who have a suspicion of having glaucoma or even a different eye problem should avoid it or consult their physicians before starting it.

Can I take Dicyclomine if I have some obstructive disease?

Another problem in which is forbidden to take Dicyclomine is obstruction of any kind. There are many obstructive diseases and them obstruction can be of many kinds like intestinal obstruction or stomach obstruction. There might also be a urinary obstruction or esophageal obstruction and so on. The list of obstructive diseases is very long but what we have to remember is that we should not take an anticholinergic drug like Dicyclomine in an obstructive disease. It won’t only worsen the blockage or obstruction of the area but it would create severe complications. And the complications would prove to be very harmful to the human body and it might make both of your diseases even more severe and complicated. If you have also had a apart of your bowel removed by any kind of procedure like colostomy or ileostomy you should avoid taking Dicyclomine then too as you would be at a higher risk of getting side affects and complications.

Can I take Dicyclomine if I have reflux esophagitis?

Reflux esophagitis is another condition in which taking Dicyclomine would be harmful. Reflux esophagitis is a condition in which the stomach contents along with the acid shoots up into the esophagus and damages it. This causes ulceration of esophagus which later changed into inflammation leading to fibrosis and stricture formation. This effects the motility of the esophagus to a great extent. Thus, if in this condition, the patient is also taking Dicyclomine, which is an anticholinergic, it would be very harmful. This might lead to high-risk complications too. Thus Dicyclomine should not be taken in reflux esophagitis.

Can I take Dicyclomine if I have ulcerative colitis?

Another severe condition/ disease is ulcerative colitis which is basically a long term condition in which there are ulcer formation and inflammation of the colon and the rectum. It can be very painful and complicated. The most common symptoms include diarrhea which is often mixed with blood and abdominal pain. Some other complaints also include anemia, weight loss and fever and other signs and symptoms of general inflammation. Some very harmful complications of ulcerative colitis includes mega colon and colon cancer. All this can be aggravated if a patient starts taking Dicyclomine. Its due to the fact that already ulceration and inflammation is happening which would eventually lead to strictures and blockage of the area and in that situation Dicyclomine would reduce the motility of the area and cause harmful effects.

Can I take Dicyclomine if I have acute haemorrhage?

Hemorrhage also was known as bleeding can be acute or chronic and Dicyclomine is contraindicated in this condition. Acute haemorrhage is basically bleeding from the circulatory system. It can be internal or external. In the internal acute haemorrhage the blood is leaked out from the blood vessels inside the body while if the bleeding is external it comes out via any body orifices like vagina, mouth, anus, nose or ear. It might also come through the skin after a breakthrough. Acute haemorrhage can cause many disadvantages as well as it can cause hypovolemia. And massive hypovolemia can cause death. Now if we talk about the usage of Dicyclomine its totally contraindicated in this condition as it can exaggerate the condition. Acetylcholine is a muscle contractor released by the nerves which help the muscles to contract. So these anticholinergic drugs mainly cause the obstruction of the acetylcholine receptors so the effect of acetylcholine is diminished. So Dicyclomine causes the relaxation of the muscles. When the muscles are relaxed blood vessels are dilated which causes an increase in the flow of blood. Thus, this drug can be harmful to patients who have acute haemorrhage and they should avoid taking it. So one should always consult your doctor if this problem arises or in this situation.

Can I take Dicyclomine if I have acute Myasthenia gravis?

Myasthenia gravis is an autoimmune condition and a long-term neuromuscular disease. This disease occurs due to the formation of antibodies in the body which destroys or blocks the nicotinic acetylcholine receptors at the junction of the muscle and the nerve. This leads to the inability of the nerve to initiate muscular contraction.  It usually occurs in muscles of the face, eyes etc. Thus in a diseases where muscle contraction is already a problem, giving a drug like Dicyclomine which is stopping those contractions and relaxing the muscles would create bigger problems. Thus for patients with myasthenia gravis are advised not to take Dicyclomine as it can be harmful for them than being useful. It would have a negative effect on the condition and might have a bad interaction with the drugs the patient is taking for myasthenia gravis. So one should always consult your Doctor if this problem arises or in this situation.

Can I take Dicyclomine if I have Hyperthyroidism?

In hyperthyroidism relaxation of muscles is already taking place and its distorting the normal functions of the body. Thus Dicyclomine is contraindicated in this condition. So the patients with Hyperthyroidism should avoid taking it. The people who have Hyperthyroidism or taking medicine for it are contraindicated to take any form of Dicyclomine as this adds up to the effect of hyperthyroidism and messes with the bodily normal functions. So one should always consult their doctor if this problem arises or in this situation like what alternative should they use if they have to use Dicyclomine for its indications.

Can I take Dicyclomine if I have some heart disease?

The people who or taking medicine for it are contraindicated to take any form of Dicyclomine as this drug has a negative effect and interacts with the drugs they might be taking for heart disease. So, one should always consult your doctor if this problem arises or in this situation.

Can Dicyclomine cause fever?

Dicyclomine is a drug which can be beneficial in many conditions but it may cause some side effects. One of the side effects includes fever. This is due to the fact that this drug Dicyclomine reduces the body’s ability to cool off so it shouldn’t be given to people who have a high temperature or might have it and Dicyclomine would have an exaggerated effect on it.

Can Dicyclomine cause blurred visions?

This drug can be harmful to patients who have blurred vision and they should avoid taking it. The people who have blurred vision or taking medicine for it are contraindicated to take any form of Dicyclomine as this drug has a negative effect and interacts with the drugs they might be taking for blurred vision. So one should always consult his/her doctor if this problem arises or in this situation. Dicyclomine basically increases the pressure in the eyes and thus in blurred vision, this pressure is very harmful. You should always go to the doctor and ask for an alternative as this might solve one of your problems but might worsen your eye problem. You cant surely take that for granted as eyes are one of the major organs. People who have a suspicion of having glaucoma or even a different eye problem should avoid it or consult their physicians before starting it.

Can Dicyclomine cause psychosis?

Dicyclomine has many useful indications like its used in irritable bowel disease, while all these good things about it, it should be known that it might cause psychosis too. Some individuals are sensitive and shouldn’t be given anticholinergic and while Dicyclomine is an anticholinergic so it should be avoided. Some signs and symptoms which one can experience are as follows:

  • dysarthria
  • disorientation
  • insomnia
  • confusion
  • fatigue
  • anxiety
  • euphoria
  • hallucinations
  • decreased agitation
  • short-term memory loss
  • mannerisms
  • ataxia
  • coma
  • death

This type of psychosis is also called as anticholinergic psychosis. It should be avoided as after coma it might exaggerate more and lead to death. In such situations, doctor should be consulted.

Dicyclomine dosage forms and strengths

This drug is available in following formulations: tablet, capsule, or solution that should be taken by mouth in doses of 10 mg and 20 mg. It also comes as an solution for injection in doses of 10 mg/5ml.

Oral dosage and administration in adults

20 mg is the recommended dose initially four times a day. If no side effects occur so after the use of initial dose for one week double the dose to 40 mg four times a day. If the efficacy is not attained even with 80 mg and side effects are experienced within the two weeks of usage so it should be stopped.

Intramuscular Dosage and Administration in Adults

The intramsucular approach is advised for the Injection of Dicyclomine. It should not be given by any other route. It should be given in 10 mg to 20 mg four times a day and not more than that. If the patient can’t takes oral medication so the drug Dicyclomine is given via injection and should only be given for 1 to 2 days.

dicyclomine dosage

Dicyclomine highest dose

The highest dose that can be given is maximum 80 mg daily for a time period which must not be longer than 2 weeks. The safety of this drug above these levels of dosage has not been documented. So this is the maximum amount of the drug that can be given over the period of maximum 2 weeks. If the dose is exceeded or the same dose is given for longer time periods, then there will be side effects of this drug.

Dicyclomine and bloating

Dicyclomine can cause bloating. Bloating is one of the many side effects of this drug. If a patient feels or complains of bloating with the use of Dicyclomine, then the patient should immediately contact a doctor.

Dicyclomine side effects

Usually, Dicyclomine is used for IBD and to block muscarinic receptors but it also carries some side effects too.

The side effects include

  • dry moth
  • abdominal bloating
  • blurred vision
  • stuffy nose
  • dry eyes
  • rash
  • confusion
  • nausea
  • vomiting
  • agitation
  • flushing
  • tachycardia
  • lightheadedness
  • constipation
  • dizziness
  • difficulty in urinating
  • weakness
  • headache
  • drowsiness
  • nervousness

The normal dose is around 20 to 40 mg which is given 4 times daily. So if this prescribed doe is exceeded or the drug doesn’t suit someone so that person starts to have these side effects. Some people might not be compatible with Dicyclomine and so they might have the following allergic reactions:

  • Difficulty in breathing
  • Hives
  • Swelling of mouth, lips, face, tongue or throat.

There might be some complicated and serious side effects like

  • Severe stomach pain
  • Constipation
  • Diarrhea
  • Hallucinations
  • Bloating
  • Chest Fluttering
  • Dry Skin
  • Confusion
  • Thirst
  • Behavioral Changes

How to take Dicyclomine?

Dicyclomine is usually taken 20-40 mg, 4 times daily. Some physicians may change doses to obtain best results. It should be taken with a full glass of water. The dose should be measured accurately and not taken by the rough idea. This can be dangerous. The drug should be kept away from moisture. It should be kept at room temperature. The patient should take the dose exactly as the doctor prescribes.

Dicyclomine and kidney stones

Dicyclomine should not be taken if a person has kidney stones or any other kidney damage or problem. It could aggravate the condition in the patient of kidney stones or any other kidney disease.

Is Dicyclomine addictive?

Dicyclomine can be addictive. A few cases have been reported but if the dose is taken according to prescription, then there are almost nil chances of addiction of this drug.

Can I abrupt Dicyclomine therapy suddenly?

If this therapy is abrupted suddenly, it may result in a few adverse effects on the gut. These effects may include worsening of spasms of the intestines or the spasms of the intestines may not get better at all. So this therapy should only be abrupted after consulting the doctor. Sudden cessation of the therapy will result in withdrawal symptoms.

Can Dicyclomine cause withdrawal effects?

Yes, Dicyclomine can cause withdrawal effects in its users. If the patients have been using this drug for a reasonably long time and the doses have been high and regular, then there will be withdrawal symptoms. The withdrawal symptoms may include dizziness, vomiting and sweating. These symptoms of withdrawal can be prevented if the dose is reduced gradually.

Precautions and warnings during Dicyclomine use

  • If the environmental temperature is high, heat prostration can occur with drug use including fever and heat stroke due to reduced sweating. If symptoms occur, the drug should be discontinued and supportive measures should be taken.
  • Diarrhea may be an early symptom of provoked incomplete intestinal obstruction, especially in patients who have ileostomy or colostomy. In this case, treatment with dicyclomine would be contraindicated and possibly harmful.
  • Dicyclomine may produce drowsiness or blurred vision. The patient should be warned not to engage in activities requiring mental alertness, such as operating machinery or performing hazardous work while taking this drug.
  • Psychosis can be also caused and it has been reported in sensitive and predisposed individuals given anticholinergic drugs. CNS signs and symptoms may include: disorientation, confusion, short-term memory loss, dysarthria, hallucinations, ataxia, coma, euphoria, decreased anxiety, fatigue, insomnia, agitation and mannerisms, and inappropriate affect. These CNS signs and symptoms usually resolve within 12 to 24 hours after discontinuation of the drug.
  • There are reports that administration of Dicyclomine hydrochloride oral solution to infants has been followed by serious respiratory symptoms including signs and symptoms such as: dyspnea,  breathlessness, shortness of breath, respiratory collapse, apnea, asphyxia,  syncope, seizures, pulse rate fluctuations, muscular hypotonia, and coma. Death has been also reported. No causal relationship between these effects observed in infants and Dicyclomine administration has been established. Dicyclomine is contraindicated in infants younger than 6 months.

Dicyclomine contraindications

  • Obstructive uropathy
  • Obstructive disease of the gastrointestinal tract
  • Severe ulcerative colitis
  • Reflux esophagitis
  • Unstable cardiovascular status in acute hemorrhage
  • Glaucoma
  • Myasthenia gravis
  • Evidence of prior hypersensitivity to this drug or other ingredients in this formulation
  • Infants less than 6 months of age
  • Nursing Mothers

Who should avoid taking Dicyclomine?

Use Dicyclomine with caution in patients with:

  • Autonomic neuropathy
  • Hepatic or renal disease
  • Hyperthyroidism
  • Ulcerative colitis-large doses may suppress intestinal motility to the point of producing a paralytic ileus and the use of this drug may precipitate or aggravate the serious complication of toxic megacolon
  • Hypertension
  • Coronary heart disease
  • Congestive heart failure
  • Cardiac tachyarrhythmia
  • Hiatal hernia
  • Known or suspected prostatic hypertrophy
  • Investigate any tachycardia, especially in patients with arrhytmias before administration of Dicyclomine since it may increase the heart rate.

Can Dicyclomine be taken on an empty stomach?

Dicyclomine should always be taken on an empty stomach and should be taken around 30 minutes before having a meal. Do not use it otherwise unless prescribed by the doctor. The best effects of this drug are observed when it is taken on an empty stomach.

Dicyclomine and weight loss

Dicyclomine may cause immediate weight loss in the person taking it. This is due to the fact that this drug causes a visible decrease in fat absorption, so this may result in decreased weight.

How long does Dicyclomine take to work?

It must be taken about 30 minutes before meals. It is usually used 20mg 4 times daily for about 2 weeks. This is the usual time that this drug takes to perform its complete action and show proper results.

How long does Dicyclomine stay in your body?

A person who takes Dicyclomine daily and if he stops taking it the blood tests would show it in the blood and system for like Approximately 48 to 72 hours. It maybe lesser in urine and longer in hair.

Dicyclomine during pregnancy

Dicyclomine belongs to category B of pregnancy drugs which means that animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. Animal studies in rats and rabbits have revealed no evidence of harm to the fetus with this drug. Adequate and well-controlled studies have not been conducted in pregnant women. Dicyclomine should be used during pregnancy only if clearly needed

Dicyclomine during breastfeeding

This drug does appear in the milk of the female. So it is advised not to continue breastfeeding while taking this drug. One should either discontinue the usage of this drug or breastfeeding. Both things should not be done simultaneously.

A single case has been reported of a breast-fed 12 day old infant who developed apnea whose mother was receiving dicyclomine. A causal relationship between dicyclomine and apnea could not be confirmed. Similar adverse reactions have occurred with direct administration of dicyclomine to infants.

Can geriatric patients use Dicyclomine safely?

The kidneys of an elderly person are not as efficient. So the excretion of this drug will be heavily affected as most of this drug i.e. 90% is excreted in the urine. Therefore the drug is not eliminated from the body in due time and it stays in the body for longer periods of time. This results in more amounts of the drug in the body and also the time of drug in the body increases, so the risk of side effects also increases in the elderly people.

Dicyclomine overdose

Dicyclomine should be used 20 mg 4 times per day. If it used more than this amount, adverse effects might be there. If the dose is more than 80 mg 4 times a day, for more than 2 weeks, then this will be labelled as overdose the drug which will surely result in adverse effects.

Some of the effects of the overdose of Dicyclomine include:

  • Dilated pupils
  • Headache
  • Dry mouth
  • Hot and dry skin
  • GI disturbances
  • Dizziness
  • Excitement
  • Psychosis
  • Difficulty in swallowing

Dicyclomine absorption, metabolism and elimination

When this drug is taken orally, most of it is absorbed in the GIT. Almost 67% of this drug is absorbed in GIT. About the metabolism, not many studies have been done so its metabolism is largely unknown and not many theories are present which represent the metabolism of this drug. As far as the elimination of this drug is considered, when taken orally, most of the dose is excreted in urine and a small amount is excreted in feces. Around 90% of the drug is eliminated through urine and only a small amount i.e. 10% is excreted through urine.

Can I drink alcohol while taking Dicyclomine?

If this drug is taken along with alcohol, then this may increase the state of drowsiness and dizziness of the patient. The combination of alcohol and Dicyclomine will result in a severe decrease in mental alertness of the patient. So, it is recommended that this drug should not be taken with alcohol.

Can I take Dicyclomine if I have arrhytmias?

Patients with tachycardia should be monitored closely during therapy with anticholinergic agents such as dicyclomine. Tachycardia is produced by blocking normal nervus vagus inhibition of the SA node. Paradoxically, bradycardia may occur due to central vagal stimulation which may occur prior to peripheral cholinergic blockade.

Can patients with renal or liver disease take Dicyclomine safely?

Patients with kidney or liver diseases are advised not to take this drug as this may aggravate the condition of their kidney or liver disorder. Although there has been no significant study that may show any link of this drug to the liver enzymes. Liver enzymes neither elevate nor depress by this drug.

Can Dicyclomine cause respiratory problems?

There have been no reported cases of dicyclomine causing any respiratory problems. Dicyclomine helps relax smooth muscles so it might cause bronchodilation. So it may open the airways a little bit more than normal.

Can I take Dicyclomine with MAO inhibitors?

Only minor and weak interactions might be there. There is not much information available about this interaction but usually, there is no harmful interaction so it is considered safe to use.

Can I take Dicyclomine with quinidine?

There is no specific interaction between these two and these are mostly safe to use along with each other. Minor reactions do not cause any harms anyways. It is safe to use quinidine while a patient is still using dicyclomine. Both drugs do not interfere with each other’s action and therefore there is no harm in taking both of these drugs at the same time.

Can I take Dicyclomine with Benadryl?

The use of dicyclomine with Benadryl might result in some elevated levels of some of the side effects such as drowsiness, memory problems, confusion, blurred vision, dry mouth, flushing, heat intolerance, sweating, abdominal cramping, constipation, irregular heartbeat, difficulty in urinating and confusion. Alcohol should not be used while these medications are being used. The worsening of side effects is most likely to occur in patients who are elderly or are in very poor condition. The use of these medicines affects the level of mental alertness in the patient. So, the patient should avoid doing any work which requires attention or alertness such as driving etc.

Can I take Dicyclomine with lorazepam?

Enough studies have not been to show any harmful interactions between the two. So it is safe to use the two drugs along with each other.

Can I take Dicyclomine with Keppra?

There might be minor interaction between the two drugs but no studies have shown any harmful reaction or adverse effect by the use of the two drugs with each other. So these drugs can be used safely with each other.

Can I take Dicyclomine with Zofran?

There have been no harmful interactions seen between these 2 drugs when they are taken together. Minor interactions, if occur, do not cause any adverse effects. Studies show that it is totally safe to use these two drugs together as there is no reactions between two drugs which might be harmful.

Can I take Dicyclomine with Xanax?

Xanax and dicyclomine are totally fine to use along with each other because there have been no reported interactions between the two. If any interaction occurs, its value is very minor and it does not cause any harm.

Can I take Dicyclomine with Bisoprolol?

Dicyclomine frequently cause drowsiness and other central nervous system-depressant effects that may be additive with those induced by beta blockers. In addition, these agents may increase heart rate and theoretically may counteract the bradycardia effects of bisoprplol. Pharmacokinetically, anticholinergic agents may delay the gastrointestinal absorption of beta blockers and other drugs that are administered orally.

Can I take Dicyclomine with Digoxin?

Only very minor drug interactions are present. Minor interactions cause no harm or any kind of damage to anything. So, yes, digoxin can be taken along with dicyclomine.

Can I take Dicyclomine with metoclopramide?

Metoclopramide and dicyclomine are safe to use if both drugs are taken at the same time for a therapy. These drugs have no harmful interactions ant they do not cause any decrease in each other’s absorption into the systems of the body.

Can I take Dicyclomine with corticosteroids?

Corticosteroids and dicyclomine do not interact with each other. Minor interactions are not significant at all as they do not affect the actions of each other on different systems of the body. Therefore it is safe to use dicyclomine with corticosteroids.

Can I take Dicyclomine with Klonopin?

There is no interaction between the two drugs and it is safe to use both of these at the same time during a therapy because these drugs do not cause any effect on the absorption or the effects of the other drug on the body.

Can I take Dicyclomine with Tylenol?

Anticholinergic agents such as dicyclomine may delay orr decrease the gastrointestinal absorption of acetaminophen by reducing gastric motility and delaying gastric emptying. However, the clinical relevance is probably minimal.

Can I take Dicyclomine with Hydrocodone?

There is a moderate drug interaction between dicyclomine and hydrocodone. If these drugs are used together, then the effect of any one of the drugs can become enhanced. This may result in thinking impairment of dull judgment. Effects such as drowsiness, memory problems, confusion, blurred vision, dry mouth, flushing, heat intolerance, sweating, abdominal cramping, constipation, irregular heartbeat, difficulty in urinating and confusion maybe observed. Alcohol should not be used while these medications are being used.

Can I take Dicyclomine with antacids?

Only minor interactions might be there as much studies have not been done on the effects of both drugs on each other. Minor interactions are not significant as they do not affect the action of the other drug on the body.

Can I take Dicyclomine with Symethicone?

Yes, dicyclomine is totally safe to use with simethicone and both drugs have no effect on the absorption of each other. Therefore it is safe to say that there are no adverse effects observed when the two drugs are used together.

Can I take Dicyclomine with Gabapentin?

Only very minor drug interactions are present. Minor interactions cause no harm or any kind of damage to anything. So, yes, gabapentin can be taken along with dicyclomine.

Can I take Dicyclomine with Ambien?

There is no specific interaction between these two and these are mostly safe to use along with each other. Minor reactions do not cause any harms anyways. It is safe to use ambient while a patient is still using dicyclomine. Both drugs do not interfere with each other’s action and therefore there is no harm in taking both of these drugs at the same time.

Can I take Dicyclomine with Aleve?

The use of dicyclomine with Aleve might result in some elevated levels of some of the side effects such as drowsiness, memory problems, confusion, blurred vision, dry mouth, flushing, heat intolerance, sweating, abdominal cramping, constipation, irregular heartbeat, difficulty in urinating and confusion. Alcohol should not be used while these medications are being used. The worsening of side effects is most likely to occur in patients who are elderly or are in very poor condition. The use of these medicines affects the level of mental alertness in the patient. So, the patient should avoid doing any work which requires attention or alertness such as driving etc.

Can I take Dicyclomine with ibuprofen?

The use of dicyclomine with Ibuprofen might result in some elevated levels of some of the side effects such as drowsiness, memory problems, confusion, blurred vision, dry mouth, flushing, heat intolerance, sweating, abdominal cramping, constipation, irregular heartbeat, difficulty in urinating and confusion. Alcohol should not be used while these medications are being used. The worsening of side effects is most likely to occur in patients who are elderly or are in very poor condition. The use of these medicines affects the level of mental alertness in the patient. So, the patient should avoid doing any work which requires attention or alertness such as driving etc.

Can I take Dicyclomine with coffee?

Coffee has caffeine and there are no dangerous interactions between dicyclomine and caffeine. There are only minor interactions between the two and therefore this drug can be taken with coffee as there are no harmful consequences.

Can I take Dicyclomine with Buscopan?

Yes, buscopan can be used with dicyclomine as both drugs do not interact with each other and there are no adverse effects if these drugs are taken together. They do not affect each other’s absorption or action on systems of the body.

Can I take Dicyclomine with birth control pills?

No,  specific interaction between these two drugs have been seen and these are mostly safe to use along with each other. Minor reactions do not cause any harms anyways. It is safe to use birth control pills while a patient is still using dicyclomine. Both drugs do not interfere with each other’s action and therefore there is no harm in taking both of these drugs at the same time for a therapy.

Can I take Dicyclomine with Pepto Bismol?

Pepto Bismol can be safely used with dicyclomine and there have been no noticeable interactions between the two drugs. Minor interactions do not cause any harm anyways. Therefore these two drugs can be used with each other without facing any adverse effects.

Can I take Dicyclomine with Imodium?

This drug interaction might increase the effect of Imodium on the intestines. The use of dicyclomine with Imodium might result in some elevated levels of some of the side effects such as drowsiness, confusion, blurred vision, flushing, heat intolerance, sweating, abdominal cramping and confusion. Alcohol should not be used while these medications are being used. The worsening of side effects is most likely to occur in patients who are elderly or are in very poor condition. The use of these medicines affects the level of mental alertness in the patient. So, the patient should avoid doing any work which requires attention or alertness such as driving etc.

Can I take Dicyclomine with Omeprazole?

Omeprazole is safe to use along with dicyclomine because both drugs do not affects each other’s actions on the body. Omeprazole performs its own function properly without disturbing the metabolism and action of dicyclomine.

Can I take Dicyclomine with Potassium?

If the potassium is in solid formation, then following effects may occur. There may be some effect on stomach and intestines. Irritation, ulcer, injury or GIT bleeding may occur with its use. Nausea, vomiting, bloating, abdominal pain, black tarry stools are some of the adverse effects that might occur if these 2 substances are used with each other.  If a liquid formulation of potassium chloride is being used, then it is safe to use it with dicyclomine and the above-mentioned effects will not occur. However, it is essential to tell your doctor about any medications that you are using.

Can I take dicyclomine and meclizine?

The use of dicyclomine with meclizine might result in some elevated levels of some of the side effects such as drowsiness, memory problems, confusion, blurred vision, dry mouth, flushing, heat intolerance, sweating, abdominal cramping, constipation, irregular heartbeat, difficulty in urinating and confusion. Alcohol should not be used while these medications are being used. The worsening of side effects is most likely to occur in patients who are elderly or are in very poor condition. The use of these medicines affects the level of mental alertness in the patient. So, the patient should avoid doing any work which requires attention or alertness such as driving etc.

Can I take dicyclomine and tramadol?

There have been dangerous interactions between the two above mentioned drugs. Not many studies and experiments have been done regarding the drug interaction between the two substances. The minor interaction between the drugs is of no importance and does not affect the action of other drugs and also does not require any change in drug therapy.

What is Kolanticon?

Kolanticon is a medicine which has more than one ingredients. It is also called Kolanticon gel. This contains aluminium hydroxide, light magnesium oxide, dicycloverine hydrochloride and simethicone are the components and active ingredients of this Kolanticon gel. It is used for IBD and peptic problems. Also used for bloating, gas in the stomach, heartburn, pain, cramps, peptic ulcer, sour stomach, the pressure in GIT and irritable bowel syndrome. Kolanticon gel relaxes muscles of the GIT and this way it stops the muscle contractions. It adds magnesium to the body and it neutralizes acids in the stomach.  It also causes the breaking of gas bubbles which are formed in the gut. The side effects which will occur due to the use of this Kolanticon gel are constipation, confusion, tiredness, loss of appetite, weakness of muscles due to excessive relaxation, breathing problems, rashes and swallowing problems. These side effects will occur if the drug is overused or used without a prescription. The proper and prescribed dose should only be used, otherwise, the above-mentioned adverse effects can occur. The important point about this drug is that before taking this drug, following things should be told by the patient to the doctor. The patient should always tell the doctor if he or she is consuming alcohol, constipated, dehydrated, breastfeeding or falls in the age category of children. Kolanticon gel may interfere with or react with the following drugs. These include corticosteroids, ascorbic acid, citrates, and cellulose sodium phosphate, cephalosporin and bisphosphonate derivatives. Kolanticon gel should never be used in conditions such as myasthenia gravis, allergy, hypersensitivity, increased pressure in the eye and enlarged prostate.

What is Cyclopam?

Cyclopam is a drug which is usually used to cure smooth muscle pain and cramps etc. It is used to relieve stomach pain, menstrual pains, kidney pain and pain of cramps. It is a multi-ingredient drug which contains dicyclomine, mefenamic acid, paracetamol, dimethicone and simethicone.  The adverse effects of this medicine are vomiting, pain during urination, nausea, constipation, dry mouth, bloating, blurred vision and drowsiness. The usual dose is 80 mg per day but this 80 mg is divided into four parts for each day and this drug should be given only for maximum 2 days.

What is Metal-SPAS?

It is a drug which is actually a combination of mefenamic acid and dicyclomine. It is actually a smooth muscle relaxant so it is used to treat painful menstruation and other conditions like irritable bowel syndrome. The mefenamic acid in this metal-spas is a NSAID so it reduces the fever and production of prostaglandins. On the other hand, dicyclomine is an antispasmodic drug so it relaxes the smooth muscle.

What is Normaxin?

Normaxin is an antispasmodic drug. It is usually used for GIT. So it is an antispasmodic for GIT. Generic components of Normaxin include chlordiazepoxide 5mg, clidinium bromide 2.5 mg, and dicyclomine 10mg. It is antispasmodic and is used to reduce cramps in stomach. It slows down the natural movement of the gut in humans and so it relieves the cramps. It also acts on brain nerves and therefore reduces the pain. This drug is used for painful menstruation, abdominal cramping, GIT motility disturbances, irritable bowel syndrome, severe anxiety, muscle spasm, behavioural disorders, periodic spasms, insomnia, pain in stomach, alcohol withdrawal symptoms, motion sickness, fear, peptic ulcers, pre anesthetic medication and cramps. It is a very effective medicine for all the mentioned indications.

Side effects of this medicine include abdominal bloating, weakness, headache, vomiting, blurred vision, urinary retention, upset stomach, constipation, thirst, rapid rate, respiratory arrest, movement disorder, nausea, diarrhea, taste change, loss of appetite, dizziness, lights sensitivity, drowsiness, dry eyes, eating disorder, dry mouth, change in sex drive, lethargy, increased eye pressure, sleeplessness, heartburn and vomiting.it is usually taken as one or two tablets three to four times a day. The dose is taken before meal. A few things should always be kept in mind while using this drug. The person using this drug should not be suffering from any hepatic disease or renal impairment.

Can I get ‘’high’’ on Dicyclomine? Is this drug abusive?

This drug is not abusive. No reported cases of abuse of dicyclomine have been reported yet. This drug causes relaxation of smooth muscles of the body as it as an anticholinergic drug and so it relaxes smooth muscles of the body.

Is Bentyl a controlled substance?

Bentyl is not a controlled substance. It is very safe to use for humans and there have been no harms due to its use. 20mg of this drug 4 times a day is safe for humans to use. There have been no cases of risk during pregnancy.

Dicyclomine drug test

Usually, Bentyl does not show on a drug test. If it appears on the drug test, it might appear as benzodiazepines, but such cases only happen when the quality of the drug test is poor. Otherwise, dicyclomine does not appear on a drug test in normal conditions.

Dicyclomine for dogs

Dicyclomine can be used for dogs. It is an anticholinergic drug that reduces the spasm of smooth muscles of urinary tracts and GIT. It can use for IBD in dogs. It can be used for the treatment of diarrhoea also. As it is an antispasmodic drug, it will reduce the contraction of smooth muscles of GIT and urinary tract. If the side effects of this drug start to appear in the animal, make sure to get it checked from the vet.

Keppra, Keppra XR (levetiracetam) dosing, indications, interactions

About Miljan Krcobic 240 Articles
My name is Miljan Krčobić. I was born on 14th of November 1989. in Negotin, Serbia, where I finished elementary and high school. In June 2015 I graduated from the Faculty of Pharmacy in Belgrade and thus acquired the title Master of Pharmacy. From the July of 2015 to January 2016 I worked in a pharmaceutical company Hemofarm a.d.(Member of STADA group) based in Vrsac, Serbia, as an expert associate for GMP compliance within the sector Quality Assurance. I am currently working in a pharmacy called Zivkovic in Negotin. As a freelancer I write medical articles on Elance and Upwork.