U15 pill identification

What is the U15 pill?

The pill with imprint U15 is identified as acetaminophen and oxycodone hydrochloride in the strength of 325 mg / 5 mg respectively. It is of white color and capsule shaped. The main supplier of this medicine is Aurolife Pharma LLC.

This combination medication is used for the treatment of chronic pain and comes under the narcotic analgesic combinations. The risk of this drug cannot be ruled out during pregnancy.

  • Imprint: U15
  • Strength: 325mg/5mg
  • Color: White
  • Size: 12 mm
  • Shape: Capsule-shape
  • Availability: Prescription only
  • Drug Class: Narcotic analgesic combinations
  • Pregnancy Category: C- risk cannot be ruled out
  • CSA Schedule: 2 – High potential for abuse
  • Labeler / Supplier: Aurolife Pharma LLC.
  • Inactive Ingredients: Pregelatinized starch, stearic acid, povidone, crospovidone, and lactose

Active ingredients of U15 pills and their identification

U15 pill contains oxycodone and acetaminophen in strength:

Oxycodone Hydrochloride USP 5 mg
Acetaminophen USP 325 mg

Oxycodone occurs as a white, odorless, crystalline powder having a saline, bitter taste and is a known semi-synthetic opioid analgesic.

Acetaminophen is a slightly bitter, white, odorless, crystalline powder, categorized as a non-opiate, non-salicylate analgesic and antipyretic.

U15 pill chemistry


Molecular structure:

U15 pill chemistry

Molecular formula: C18H21NO4

Molecular weight: 315.369 g/mol

IUPAC Name: (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one

Drug class: This compound belongs to the class of organic compounds known as phenanthrenes and derivatives. These are polycyclic compounds containing a phenanthrene moiety, which is a tricyclic aromatic compound with three non-linearly fused benzene.


U15 pill identification

Molecular formula: C8H9NO2

Molecular weight: 151.165 g/mol

IUPAC Name: N-(4-hydroxyphenyl) acetamide

Drug class: These compounds belong to class of organic compounds known as 1-hydroxy-2-unsubstituted benzoids.

U15 pill uses

U15 pill contains oxycodone and acetaminophen as a combination which is indicated for the relief of moderate to moderately severe pain.

U15 pill legal status

Acetaminophen/Oxycodone 325 mg/5 mg is categorized as a Schedule 2 controlled substance under the Controlled Substance Act (CSA). This drug possesses a high potential for drug abuse.

What are different brand names for acetaminophen/oxycodone combinations?

U15 come under various brand names such as Endocet, Magnacet, Narvox, Percocet, Perloxx, Roxicet, Roxilox, Tylox, Xartemix XR, and Xolox

U15 pill price and prescription

Generic oxycodone/acetaminophen is covered by almost all Medicare and insurance plans. However, you may also find some lower pharmacy coupons or cash prices.

The most common version of oxycodone /acetaminophen is of around $22.31, which is 79% off the average retail price of $104.69 and lowest price at GoodRx.

U15 pill mechanism of action

Our central nervous system contains mu, kappa, and delta opioid receptors and Oxycodone acts as a weak agonist on these receptors.

Oxycodone primarily binds on the mu-type opioid receptors and stimulates the exchange of GTP (Guanosine triphosphate) for GDP (Guanosine Diphosphate) on the G-protein complex.

As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase.

Subsequently, the inhibition of GABA, dopamine, acetylcholine, and noradrenalin takes place. Opioids also close the calcium channels which are voltage operated and open the potassium channels which results in the hyperpolarization and reduced neuronal excitability.

Acetaminophen comes under the class of weaker analgesics. This drug increases the pain threshold by inhibiting the isoforms of enzyme cyclooxygenase, COX1, COX2, and COX3.

These enzymes are involved in prostaglandin synthesis. Acetaminophen does not inhibit the COX enzyme in the peripheral tissues, just like other NSAIDs, therefore also not shows the anti-inflammatory effects at the periphery.

As per some studies, Acetaminophen inhibits the COX3 which is different from COX1 and COX2, still, the exact mechanism of acetaminophen is not clear.

Acetaminophen also possesses antipyretic properties which are caused by its direct effects on the heat-regulating centers of the hypothalamus.

U15 pill side effects

Common Side Effects of U15:

Tell your doctor if any of the following side effects become severe or don’t go away:

  • Upset stomach
  • Constipation
  • Drowsiness
  • Dry mouth
  • Blurred vision

Serious Side Effects of U15:

You should tell your doctor immediately if you experience any of the symptoms:

  • Slow heartbeat
  • Shallow breathing
  • Lightheadedness
  • Confusion
  • Unusual thoughts or behaviors
  • Seizures
  • Problems with urination
  • Signs of an allergic reaction (may include hives, rash, itching, chest tightness, or swelling of the face, lips, tongue, or throat)

CanU15 pill cause dependence?

U15 pill comes under Schedule 2 controlled substance. Acetaminophen is less likely to cause dependence but oxycodone possesses abuse liability similar to morphine.

These are the substances which are used in analgesia and can be abused to a higher extent. This medication should not be stopped abruptly because it can cause severe withdrawal symptoms.

U15 pill pharmacokinetics

Absorption and distribution: The mean absolute oral bioavailability of oxycodone is reported 87%. It is bind to human plasma protein in vitro about 45%. The enzyme CYP2D6 metabolizes the oxycodone to oxymorphone.

After a single oral dose of oxycodone, the free metabolites such as noroxycodone, conjugated oxycodone and oxymorphone are excreted in human urine. Approximately 8% to 14% of the dose is excreted as free oxycodone over 24 hours after administration.

After oral administration of acetaminophen, its metabolism and excretion are rapid and almost complete from the GI tract.

It will take 4 hours for complete absorption of the drug and is relatively distributed throughout the body fluids. Cytochrome P450 microsomal enzyme is responsible for the metabolism of the acetaminophen in the liver.

About 80% – 85% of the acetaminophen in the body is conjugated principally with glucuronic acid and to a lesser extent with sulfuric acid and cysteine. Within the 1st day, 90% to 100% of the drug is recovered in the urine after hepatic conjugation.

How long U15 stays in the system?

A combination of acetaminophen and oxycodone is present in the U15 pill. Acetaminophen has a half-life of 2.5 hours to 3 hours, whereas oxycodone has the elimination half-life of 3 to 4 hours.

The complete elimination time of a drug is 5 times to that of the half-life of a drug, therefore acetaminophen will completely eliminate from your body in 1 to 2 days and oxycodone will completely eliminate in around 2 to 3 from your body.

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