Archive for May, 2017

Polysporin powder

May 30 2017 Published by under Medicines

What is Polysporin Powder?

Polysporin powder is a first aid antibiotic that is used to prevent infection in minor cuts, scrapes, abrasions and burns.

Polysporin powder contains active ingredients (in each gram) as:

  1. Bacitracin 500 units
  2. Polymyxin B 10,000units

Polysporin powder also used in surgical procedures and skin disorder treatments to decrease the risk of wound infection. It should be applied every 2-4 hours in order keep area infection free.

what is polysporin powder used for

How does Polysporin work?

Polysporin acts on bacteria responsible for infection in open wounds, cuts, and abrasions. Polysporin contains bacitracin and polymyxin B, which act against gram-positive and gram-negative bacteria as well.

Polymyxin B:

It acts as a bactericidal antibiotic that interferes with phospholipids of bacterial cell wall and promotes the leakage of intracellular components that leads to subsequent cell death. It acts against gram-negative organisms mainly that include P. aeruginosa, E.coli, Klebsiella species and Enterobacter.

Bacitracin:

It interferes with the incorporation of amino acid into cell walls that leads to no bacterial cell growth. It mainly acts on gram negative bacteria such as staphylococci, streptococci, anaerobic cocci, corynebacteria, and clostridia.

Polysporin powder has great absorption when applied to cuts and abrasions. However, systematic absorption of polysporin powder is very minimal when applied to denuded or intact skin.

What are some uses of polysporin powder?

polysporin powder substitute at CVS

Polysporin powder has a great advantage in dermatology and skin infection disorders.

  1. Polysporin is used in treating pyoderma, impetigo, ecthyma and sycosis and shows great results when applied frequently (when applied hourly).

Results as per finding of a clinical trials are:

  • Impetigo – Cured in 1 day; healed in 7 days
  • Ecthyma – Cured in 2 weeks
  • Pyogenic paronchia – Cured in 2 weeks
  • Sycosis vulgaris – Healed up to 3 weeks
  1. Polysporin shows marked improvement in superficial wounds when applied thrice daily. As per an Australian study:
  • It showed 15% reduction in infection rate by microbiologic criteria
  • It increased the reepithelialization rate of wounds up to 25% and reduced scarring and dyspigmentation as compared to other agents.
  1. Polysporin is superior to other agents such as Neosporin because:
  • It checks open sores and wounds from getting infected and fastens the process of sore healing.
  • It can be used by the patients who are sensitive to Neomycin (an ingredient used in Neosporin ointments).
  1. Polysporin is excellent agents that check and stop the growth of bacteria in the wound region.
  2. Polysporin powder is highly beneficial in treating anal fissures, Patient should clean the area before dusting a small amount of polysporin powder.

One should optimally use this medication (especially in the case of anal fissures) because it can lead to burning, irritation or redness.

How can I use polysporin powder

Polysporin is a topical formulation that should be use on the skin only.

  1. Wash your hands before application, avoid getting this medicine in your eyes or mouth. Wipe off and rinse thoroughly immediately, in case it enter inside your mouth or eyes. Avoid using this formulation in the nose, until asked by your doctor.
  2. Clean and dry the wound or affected area. Apply a light dusting of polysporin powder on the area, usually 1 to 3 times daily. Cover with a bandage if allowed. If you are applying a cream based formulation, apply a small amount of medication in a thin layer on affected area.
  3. Use a prescribed amount of medication on skin, more than prescribed amounts or large amounts of polysporin powder should not be used because it may increase the risk of side effects.
  4. You should apply the powder at the same time of the day, this will help in improvement of the wound.
  5. Consult your doctor if you don’t see any benefit from this medication.

Does polysporin cause any side effects?

Yes, like all other medicines polysporin powder can also produce side effects. Few side effects are burning, redness, itching or redness of skin. Let your doctor know about your skin conditions if any of these symptoms persists or worsens. Most of people had not shown any kind of side effects while using this medicine.

Your doctor also prescribes you the medication based on its benefits more than its side effects. Some serious side effects are balance problems, hearing problems or folliculitis. Consult your doctor immediately regarding such conditions. Excessive usage or prolonged use of this medication can result into fungal infection such as scaling, swelling or hot skin. Do not ignore any of such symptoms during use of this medication.

Seek medical attention if you see a serious allergic reaction for example rash, itching or swelling of tongue, face or throat, severe dizziness or trouble breathing.

Although very serious or rare side effects have not seen with this medication.

polysporin powder for sale

What precautions should I take while using Polysporin powder?

Take special precaution if you are allergic to polysporin, and tell this to your pharmacist or doctor before taking this medication.

  1. Tell your pharmacist regarding your medical history, skin conditions such as eczema, viral skin infections such as shingles, chicken pox or cold sores, so that he or she can change the medicine accordingly.
  2. If you are undergoing any kind of surgery, tell your doctor that you are taking polysporin.
  3. Use this medicine in emergency only if you are pregnant and discuss its risks with your doctor.
  4. Nursing mothers should also talk to their doctors regarding its passage into the milk before they start breast-feeding.

How should I store the Polysporin powder?

  • You should store polysporin powder at 20’ to 25’C (68’F to 77’F)
  • Polysporin powder should not be refrigerated.

What to do in case of polysporin overdose?

This medicine may prove harmful if swallowed intentionally or accidentally. If you had an overdose of this medicine and feel trouble in breathing, you should call a poison center right away. Do not share this medication with others as it may be prescribed for your current conditions only. Also, you should discard the left medicine after recovery from your skin disease and should not use it again until prescribed by your doctor.

How does Alka-Seltzer work? Is Alka Seltzer good for a hangover?

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Klonopin ‘’high’’

May 26 2017 Published by under Drug Abuse

What is Klonopin?

Klonopin is a Brand name for an anxiolytic prescription medication that contains benzodiazepine drug clonazepam as an active ingredient.  Clonazepam is used as anti-seizure medicine in adults and children.  It also affects neurotransmitters in the brain that may be unbalanced in patients with anxiety disorders.

This medicine comes in the forms of a tablet and disintegrating (dissolving) tablet to be taken by mouth. Klonopin is available in doses of 0.5 mg, 1 mg and 2 mg.  Klonopin is most commonly prescribed as an antiepileptic drug in the treatment of the Lennox-Gastaut syndrome (epileptic petit mal variant), akinetic and myoclonic seizures and for the treatment of panic disorders including agoraphobia.

FDA first approved clonazepam in 1975 under the brand name Klonopin, which was originally manufactured by Roche Drug Company. Many manufacturers now produce generic clonazepam. In many parts of the world it is commonly used as a recreational drug.

Is the drug Klonopin addictive?

What is Klonopin used for?

FDA approved, label indications, for Klonopin are:

  • Akinetic seizures
  • Burning Mouth Syndrome
  • Essential Tremor
  • Lennox-Gastaut Syndrome (LGS)
  • Mixed manic depressive episode
  • Panic Disorders
  • Rapid Eye Movement Sleep Disorder
  • Restless Legs Syndrome (RLS)
  • Tardive Dyskinesia
  • Tourette’s Syndrome
  • Acute Manic episode
  • Myoclonic seizures
  • Refractory absence Seizures

How Klonopin works in the body?

Clonazepam which is the active ingredient of Klonopin, works by causing allosteric interactions between benzodiazepine receptors and GABA – gamma-aminobutyric acid receptors in the CNS, increasing the effects of neurotransmitter – GABA, which is the major inhibitory neurotransmitter in the CNS. Final results are increased inhibition of the ascending reticular activating system.

Can Klonopin makes you ‘’high’’?

Klonopin is often used in nonmedical purposes and sold illegally. The DEA considers all benzodiazepines drugs including clonazepam from Klonopin to be Schedule IV drugs, meaning they are safe with a prescription and medical oversight. Thus, these drugs are not as closely monitored as prescription opioid drugs, which are Schedule II.

Although it is prescription medicine, Klonopin is considered as top-ten most addictive and abusive sleeping aid.  The reason for that is because Klonopin can produce a euphoric effects and high but also drowsy calmness sense that can be very pleasant and thus abusive. When you take Klonopin, your brain becomes depressed and this causes a short, but euphoric “high”.

All benzodiazepines are known to have a high risk of dependence, tolerance and addiction thus the general recommendations is that these drugs should never be used for a long-term. Clonazepam is among the most abusive and addicted benzodiazepines drugs and the major reason for that is its rapid onset of action and a long elimination half-life time.

This drug has fast absorption and passes through the brain in an hour, whereas it can stay in the body for close to 3 days, depending on the used dose, frequency of use and different individual factors. Because it’s effects start quickly, the body will speedily develop a tolerance and dependence on this drug.

Thus, Klonopin and other clonazepam products are labeled to be prescribed only for no more than 2 weeks, considering that longer treatment will probably cause addiction and withdrawal.

how much klonopin to get high first time

Where abusers get Klonopin?

On the streets, Klonopin is known by a number of slang terms such as: Kpin, Pin, Klons, Benzos, Tranks. The Internet becomes very easy place to get clonazepam/Klonopin without a prescription. Illicit online suppliers sell generic forms of this drug most commonly to young users in search of a suitable source of recreational drugs. Klonopin is also sold through underground sources at parties, clubs or raves.

Benzodiazepines drugs such as: Ativan (lorazepam), Xanax (alprazolam), Valium (diazepam), but also Klonopin (clonazepam) are frequently prescribed and can be found in many households. Abusers often get Klonopin from a family member or friend having legitimate prescription.

Family members may be the most common source of drugs including Klonopin. A parent, without attending, might share prescription drugs without considering the potential for dangerous side effects and drug interactions.

Between 1999 and 2010, the number of benzodiazepines prescription enlarged 4 times. Adults between the ages of 18 – 64 were the major population and thousands of them got struggle to addiction or dependence due to a prescription for these medications.

The larger number of prescriptions is the drugs are often the target of abuse since they are easy to find. Even though, Klonopin is very efficient medicine that helped many patients, outside of a prescription, it can be very harmful for those who use it for non-medical reasons.

Klonopin ‘’high’’ experience

Abusers often ground up and snort Klonopin talbets, or inject them after dissolving. This way of use enhances the tranquilizing effects of other drugs and makes more stimulants high. Recreational users often combine Klonopin together with other drugs, such as narcotics, alcohol, tranquilizers or hallucinogenics.

Taking benzodiazepines with depressants like alcohol can slow down the activity of your brain to a very dangerous rate, increasing the risk of unconsciousness, coma or death. Taking Klonopin with alcohol or other drugs can increase the risk of an overdose and death.

Here are some Klonopin ‘’high’’ experience described on Erowid website (https://erowid.org/):

 “…I took six 1 mg clonazepam tablets at 7:51pm. I also take 50 mg zoloft every day but my m.d. said these two won’t interact with each other. At 8:11pm  starting to have a bit more difficult time typing and concentrating. I’m getting thirsty. My head feels swimmy, and colors look a bit brighter… At  8:31pm I feel a simple, basic connectedness to the things around me and take even more pleasure in the small things than I usually do, like the smell of my apple-cinnamon bathroom air-freshener even…  At 8:45pm The euphoria is beginning. I feel like my apartment is the physical embodiment of all the beauty in my life and I get to walk around it and be immersed in the peace that is really inside me… I really want to sink into the cloud of my bed that makes me feel so comfortable and so safe on nights like these. It should be interesting to coordinate my movements, we’ll see how it goes. I’ll get back to you in a little bit. Well, when the tv fell on my foot instead of cursing like I normally would, I laughed really loud. I’m gonna up the ante a little bit and take 4 more 1 mg pills.  I can definitely feel the effects of the other 4 mg. The euphoria is more intense, but the drowsiness isn’t really drowsiness, just the imminent need to cuddle up in my bed with happy thoughts. However, if I should drift into sleep, it would be peaceful and full of dreams I am sure (clonazepam does that to me). Colors are brighter and sound prettier, a slight ‘body high’ where all of my being feels wrapped in a warm blanket that nuzzles and comforts me. It is at once a physical and emotional feeling. I’m gonna go relax now that I have my t.v. hooked up (however ghetto like of a hook-up it is). One more thing, I talked on the telephone to my friend a minute ago, and it was very genial but I was having a hard time communicating cuz she kept saying, ‘What?? I can’t understand you?’ And I couldn’t really understand her either. Nonetheless it was friendly. Winding down, drowsiness is starting to overcome me, I’m heading for bed and I’m sure these relaxed effects will continue well into tomorrow after I wake up. The thing about clonazepam is that the drowsiness doesn’t hit until the end of the night. It will probably take me another hour or two to fall asleep but I am definitely not capable of typing any more. “

What is a good dose to get high on klonopin on an empty stomach

Klonopin Withdrawal

Withdrawal symptoms of Klonopin will be manifested if drug is taken during long-term period and then suddenly abrupt. According this period for Klonopin and similar benzodiazepines drugs is only 2 weeks. The severity and duration of Klonopin withdrawal symptoms depends on how much and how often Klonopin is taken and by individual factors such as your height, sex, weight, age, general health.

Klonopin withdrawal symptoms are similar to the ones for alcoholism and barbiturates. Symptoms may include: seizures, anxiety, delirium, agitation, restlessness, psychosis, sweating, uncontrollable shaking, moodiness, behavioral changes, vomiting, tremor, rashes, stomach and muscle cramps, hallucinations, heart palpitations, loss of appetite, diarrhea or constipation, dry mouth, depression, hysteria and insomnia.

These symptoms may vary from person to person and some find it relatively easy to withdraw. Withdrawal syndrome usually begins 24 – 72 hours after the last dose is taken.

Symptoms seem to be more severe between 5th and 7th day. Most people need 2 weeks to achieve chemical detoxification from benzodiazepines. Some people have withdrawal symptoms for months. According to this, Klonopin withdrawal is considered as hard, if you know that heroin’s withdrawal lasts for about 3 days.

Klonopin use should never be abruptly discontinued, no matter the drug is used for medical or non-medical purpose. Klonopin discontinuation should be always followed and monitor by health professional with adequate dose reduction and tapering.

The ideal method to withdraw from Klonopin is to enter a residential treatment center and undergo detoxification with medical supervision. Some of the drugs used to help people in withdrawal are buspirone, anti-seizure drugs and antidepressants.

Klonopin overdose

Signs and symptoms of a Klonopin overdose may include:

  • Paradoxical excitation (e.g., hyperactivity, aggression, etc.)
  • Profoundly altered mental status.
  • Confusion
  • Memory loss
  • Markedly slurred speech
  • Ataxia
  • Loss of consciousness
  • Unresponsiveness
  • Coma

Overdose after Klonopin use is more likely to occur when this drug is taken together with alcohol or other drugs. Many patients overdose this drug when they mix it with alcohol or opioids such as morphine or heroine. If Klonopin is taken together with alcohol, serious interactions may occur resulting in a decrease in motor and mental function.

This interaction can also significantly slow the respiratory system leading to slowed breathing, confusion and loss of consciousness. It can also be dangerous to combine Klonopin with clozapine in some situations, as well as opioids and other drugs. Combining Klonopin with opioids or other CNS depressants may cause following side effects:

  • Slowed or labored breathing and respiratory arrest.
  • Profound dizziness/lightheadedness.
  • Extreme sleepiness.
  • Loss of consciousness/unresponsiveness
  • Coma
  • Death

When overdosed patient get to emergency room, doctors and nurses will provide supportive care and adequate monitoring to ensure that they are safe. Flumazenil is proved to be good antidote which can be administered in the hospital to neutralize the effects of an acute benzodiazepine overdose. Although this this drug also carries some risks, it is highly effective at treating an overdose.

Depending on how overdosed person recovers, he/she may stay in the emergency room until they are stabilized. In the case of intentional overdose, they will surely undergo a psychiatric evaluation before leaving the hospital. If significant respiratory depression or coma is caused as a result of overdose, patients will be referred to the intensive care unit for further care

According to medical reports, Klonopin is involved in a high percentage of drug-related episodes of overdose. For example, just in 2004, there were approximately 1.3 million emergency room cases linked to drugs overdose, of which about 40% of them were involved with nonmedical use of prescription drugs.

30% or 144,385 visits in 2004 were caused after benzodiazepines overdose, and almost 20% of the benzodiazepine patients which is about 26,238 patients were Klonopin overdoses. The vast majority of people overdosing on benzodiazepines used for nonmedical reasons are combining it with alcohol, narcotics, opiates, or other prescription drugs.

What are the signs that someone is addicted to Klonopin?

Those whose answer is ‘’yes’’ for one or more following question they can find themselves addicted to Klonopin and should seek for medical attention:

  • Are you taking Klonopin without a doctor’s prescription?
  • Do you need increased doses Klonopin in order to make it work for you?
  • Are you taking more than 4 mg of Klonopin a day?
  • Did you try to stop using Klonopin and it showed unsuccessful?
  • Do you exhibit withdrawal symptoms including anxiety and depression, when you stop taking Klonopin?
  • Do you have physical issues, such as sleep problems or dizziness after Klonopin discontinuation?
  • Is your life more difficult and stressful without Klonopin?
  • Do you mix Klonopin with other drugs or alcohol?
  • Does your family criticize you because of your drug abuse?
  • Do your loved ones think you have become more distant and moody since you began using Klonopin?
  • Do you worry that you may face consequences for breaking the law because you use Klonopin?
  • Can you take more than 2 days without Klonopin?
  • Do you feel ashamed, guilty or embarrassed because you abuse Klonopin? Are you afraid to talk about it with a doctor?

Klonopin drug-addiction treatment

Klonopin addiction and Klonopin physical dependency is not the same thing. Patients who were using Klonopin for medical purposes and with prescriptions, in appropriate amounts and as recommended by the doctor will need to go through withdrawal symptoms and may for certain built up a tolerance to the drug, but this does not have to be that patients is necessarily addicted.

Addiction has psychological nature and occurs when the drug use motivates its continuing. The addict has no choice but to keep using Klonopin. Many health professionals suggest that addiction is also a behavioral disorder, and that genetics may play important role in its development.

Many drug abusers take drug to self-medicate emotional pain. In order to achieve life free of drugs, they must learn to understand their pain, and to deal with with it and everyday life without using any drug. The majority of Klonopin abusers and addicts actually have undiagnosed ahealth issues such as clinical depression, personality disorders, unresolved childhood traumas, etc.

In order to find best way to help such cases to let go of addiction, these patients undergo a complete physical and psychological examination for determination. If some psychiatric disorder is diagnosed, such disorders need to be treated along with addiction they will be much more likely to go back into drug abuse after addiction treatment.

The first line of addiction treatment is intense counseling. Those who enter residential center will have their own counselor to help them understand themselves. These professionals can help you understand the primary cause of addiction, how to manage desires, and how to achieve abstinence on a long-term basis. Life changes will be necessarily.

Most residential treatment centers offer parties, sports, sight-seeing and other recreational activities. These treatment programs are usually fun, and addicts are also learning how to relax and enjoy life without drugs. Once addicts return home, they will probably continue in individual counseling and support meetings within their community.

How long Klonopin stay in your system?

It is necessary to consider the elimination half-life time of clonazepam in order to determine how long Klonopin will remain in your body after final dose is taken. Clonazepam has a long elimination half-life estimated beneath the range of 30 to 40 hours.  According to this it will take about 1 to 2 days to eliminate the half of the taken dose from the body.

Rendering its long elimination half-life it can be estimated that Klonopin is likely to stay in your system for about 7-9 days after the final dose is taken.  But, different sources suggest that clonazepam may have even a wider half-life range between 18.7 hours to 60 hours.  If this is the case, it could take between 4-14 days for complete elimination of Klonopin.

Moreover, it is essential to bear in mind that clonazepam is metabolized within the liver into a metabolite known as 7-aminoclonazepam. The elimination half-life of 7-aminoclonazepam is either shorter than, or similar to that of clonazepam.  According to all of this, the time needed for fully elimination of clonazepam and its metabolite 7-aminoclonazepam can be expected after 2 weeks of discontinuation.

Different factors may influence how long clonazepam will stay in your system. These factors include: age, body mass, percentage of fats, genetics, metabolic rate, liver function, co-administration of food or drugs, urinary pH, dosage and frequency of use.

Does Klonopin shows up on drug tests: urine, blood, saliva, hair?

Klonopin belong to the class of benzodiazepines drugs which are detectable on routine urine drug tests. The urine drug test that will detect Klonopin is the Xanax Drug Test / Valium Drug Test.  These tests give result for all benzodiazepine family drugs including: alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and more. Except urine tests, Klonopin can be also detected in blood, saliva and hair.

Urine test

About 2% of a clonazepam taken dose is excreted unchanged with urine. Because of that, most urine analyses measure amounts of its metabolite 7-amino-clonazepam or shortly 7-ACLO.  According to some data 7-ACLO metabolite stay detectable within urine for up to 5 days post-ingestion of a single dose.

But new findings suggest that 7-ACLO metabolite can be detected in urine for a much longer time, according to one study for more than 3-4 weeks. Higher dose and chronic users of Klonopin may have 7-ACLO positive tests for more than a month. Because of longer detetction-time period, urine tests are often more preferred than blood tests.  Urine tests are also more convenient, they are non-invasive, and fast.

Blood test

Klonopin can be easiest detected in blood after 1-2 hours of administration. Due to clonazepam’s long elimination half-life, it will probably stay detectable in blood some days after ingestion.

Moreover, clonazepam is highly lipophilic drug and it can be accumulated in fat tissues, so drug traces may appear in blood for longer durations. Since blood tests are invasive and have shorter time of detection than urine tests, they are often reserved for a hospitalized patient or in cases where a urine sample cannot be attained.

Saliva tests

Only 7-ACLO metabolites of clonazepam can be detected in a saliva sample during 5 and 6 days after ingestion. In this test 0.4 ml of oral fluid is collected from the mouth and then diluted with 0.8 ml of a preservative. This mixture is then analyzed with liquid chromatography/mass spectrometry (LC/MS).

However, the ability to detect 7-ACLO metabolites is much lower compared to other forms of testing. Saliva tests are non-invasive; however their accuracy is suboptimal, because detection of clonazepam will be only available in the cases of overdose. Thus, saliva testing is usually used as an alternative to urine testing in cases of acute overdose or abuse.

Hair tests

It has been showed that hair tests are able to detect 7-ACLO metabolite after a period of 4 month of post-ingestion. The biggest disadvantage is that they can’t detect the drug if it is recently taken. Days or weeks of Klonopin post-ingestion are needed for the drug metabolites to appear in the hair.

This method is often used by law enforcement agents to detect clonazepam used in the case of a drug-related crime.  Hair samples (15-20 follicles) are collected from a victim and then send to the lab analysis with gas chromatography/mass spectrometry (GC/MS).

Is Xanax and Klonopin (Clonazepam) the same thing?
Is it safe to take ambien and klonopin together?
Can you overdose on Tizanidine?

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Tizanidine recreational use

May 24 2017 Published by under Drug Abuse

What is Tizanidine?

Tizanidine is a short-acting muscle relaxant, prescribed mainly for reducing pain associated with multiple sclerosis, ALS or spinal cord injury. The primary use of tizanidine is to relieve increased muscle pain and muscle tone associated with multiple sclerosis. It is usually prescribed for medicinal purposes but it is taken as overdose and frequently abused.

Tizanidine is commonly available on the market with brand name Zanaflex. Tizanidine can be taken orally as it comes as tablet or capsule form. It should be taken two to three times daily with or without food. Alcohol consumption should also be avoided while taking this medication. Tizanidine should be taken as directed and should follow as per indications given on the label.

It should be noted that Tizanidine works on the central nervous system rather than the skeletal system, therefore, it has a more abusive tendency. It works by slowing the actions of nervous systems and the brain thereby relaxes muscles more easily. It enhances the presynaptic inhibition of motor neurons and reduces spasticity.

What is tizanidine prescribed for? Is Zanaflex a narcotic?

What is Tizanidine prescribed for?

Tizanidine is used for the treatment of multiple sclerosis, the condition in which nerves of the body do not function properly. Main symptoms of multiple sclerosis are numbness, weakness, bladder related problems, vision, loss of coordination and speech.

Usually, Tizanidine is prescribed to treat patients who suffer from spinal injury, stroke or brain injury also, where it relaxes muscles or nerves of the body. It helps to relieve pain arises from nerve injuries and help to produce a sound sleep. Tizanidine is not a commonly abused medicine and it is not abused by the one, who do not need any medication.

Tizanidine recreational use and abuse

Tizanidine is the drug that comes under the category of muscle relaxants, and antidepressants and muscle relaxers are mainly abused drugs. People who abuse Tizanidine are growing rapidly.  People suffer from insomnia and who are vulnerable to pain are main abusers of Tizanidine. Tizanidine is ill-treated when patients suffer from:

  • Insomnia
  • Frequent nightmares
  • Lethargy
  • Hallucinations
  • Increased Tizanidine Tolerance

Sometimes it is also used as a sleeping remedy. Tizanidine is closely related to clonidine that is commonly abused along with narcotics, which shows serious withdrawal symptoms upon cessation of the drug.  People increase the dose of tizanidine themselves in order to achieve prompt relief and certainly develop the addiction.

How is Tizanidine abused?

Tizanidine is a potent muscle relaxant but it works in a different way than the other relaxants medications available in the market. Primarily it is used for specific spinal injuries, brain injuries or multiple sclerosis but people who use to have much higher doses than recommended mostly carry out its abuse, which is highly contraindicated.

Anybody who is using tizanidine in an abusive manner or in a dose that is not recommended can expect to develop physical dependency and addiction. You should consider any contraindicated (off – label) use of this medicine as Tizanidine abuse.

Use of alcohol along with administration of Tizanidine also contraindicated because Alcohol increases the absorption of Tizanidine thereby enhances the level of drug in the bloodstream.

If taken together, Tizanidine and alcohol can cause additive effects such as memory loss, loss of sight, confusion, drowsiness or difficulty in breathing. So the use of Tizanidine with alcohol should be avoided. If you took both together, you should avoid driving or should not work on heavy duty machines.

Does Tizanidine produce withdrawal symptoms?

Withdrawal symptoms arise when patient sudden stop the intake of the Tizanidine. When you administer a medicine like Tizanidine for longer periods, it results in the formation of physical dependency.  As a result of physical dependency, your body will need more and more Tizanidine in order to get prompt and similar effects that once you received with this medication.

Unfortunately, people start taking drug improperly due to physical dependence caused by excessive usage of Tizanidine and eventually they suffer from withdrawal symptoms of Tizanidine. If you are taking Tizanidine from a long time, it should not be stopped abruptly as it may produce serious withdrawal symptoms such as

  • Hypertension
  • Elevated heartbeat/Tachycardia
  • Tremors
  • Muscle cramps
  • Anxiety and hypertonia.

These symptoms can be more prominent if not treated timely. The withdrawal symptoms can be avoided by stopping the drug slowly instead of stopping at once.

Such withdrawal symptoms are not necessarily harmful but they can disturb the lifestyle of the patient and creates the uncomfortable situation for the one who is suffering from the process alone. A very few people are lucky to cease the drug addiction by themselves but for many people, the drug withdrawal symptoms are so severe that force them for taking the drug again and thereby preventing them from getting the help they need.

tizanidine hydrochloride recreational use

 

How abuse of Tizanidine can be treated?

Tizanidine abuse should be treated as soon as you realized and aware about its withdrawal symptoms. Here are few tips that you can own:

  1. First, you should consult with your doctor and seek for the best treatment for you. You may need to undergo a detoxification process under the supervision of a medical expert team all the time.
  2. Do not try to leave this medicine abruptly. Detoxification process should never be performed without the supervision of medical service providers because it may prove dangerous for you both physically and physiologically and can result in serious withdrawal effects.
  3. Notify your health care provider regarding your Tizanidine dependency as soon as possible as it may prove fatal and disturbs your lifestyle with every passing day.
  4. Do not underestimate the value of professionals help that they can provide. There are no better people who can help you to get back on track as they have seen almost every stage addiction at every level.
  5. Being honest about your situation is an important step in going well. You have to work yourself to make changes in order to get rid of this addiction.

How long Tizanidine stays in body?

Tizanidine has half-life of 2.5 hours and its metabolites have 20 to 40 hours half-life. Therefore, Tizanidine stays for three to six hours inside your body and shows maximum effect during second and third hour. The dose of tizanidine should be repeated after every 8 hours and it should not be taken more than 3 times a day.

Does Tizanidine show up on home drug test?

No, Tizanidine will not show up on a drug screen because it does not come under narcotic drug category.  Medical service providers test for on a drug screen is for cocaine, narcotics such as morphine, valium, xanax etc.

Tizandine overdose

How long does it take for tizanidine to kick in?

Tizanidine is a lipid-soluble medicine and is less likely to dissolve in water and methanol. Therefore, one cannot rely upon dialysis only for removal of this drug from the body. Tizanidine overdose shows consistent clinical manifestations. It showed decrease in sensorium including lethargy, somnolence, confusion and coma.

Tizanidine overdose can also lead to depressed cardiac function including hypotension and reduced heart beat (bradycardia). It also seems to cause respiratory depression. Usually symptoms of Tizanidine overdose disappear in one to three days following discontinuation of this medicine.

Is the drug trazodone addictive? How much does it take to overdose on Trazodone?

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Can I take Advil and Mucinex together?

May 24 2017 Published by under Drug Interactions

What is Advil? How it works in the body?

Advil is a Brand name for a nonsteroidal anti-inflammatory drug (NSAID) that contains ibuprofen as active ingredient. Chemically it is derivative of propionic acid. Advil works by inhibiting prostaglandins, chemicals that may cause inflammation in the body. Advil is used to for alleviating fever, and to treat pain or inflammation caused by various conditions such as headache, toothache, arthritis, menstrual cramps, back pain, or minor injury.

It is an OTC product that can be bought without prescription. It is available in capsule, oral suspension, tablet, chewable tablet and extended release tablet forms in doses of 200, 400 and 600 mg and 100mg/5ml as a suspension. FDA approved ibuprofen in 1974.

Advil is contraindicated for use in children younger than 6 years of age.

What is Mucinex? How it works in the body?

Mucinex is an expectorant drug that contains guaifenesin as an active ingredient. This medicine is helpful in reducing chest congestions caused by colds, infections or allergies. Mucinex works by thinning the mucus in the airways. As an expectorant drug, Mucinex increases the output of sputum and bronchial secretions by reducing adhesiveness and surface tension.

The increased flow of reduced viscous secretions promotes ciliary clearence and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway. While Mucinex can easy symptoms, it is unable to treat the cause of congestion.

Mucinex is available in tablet, granule, and solution and liquid from. As a tablet it is available in doses of 600 and 1200 mg. As a solution and liquid it is available in dose of 100mg/5ml. FDA approved guaifenesin in 1952, and today is manufactured by Reckitt Benckiser.

Advil and Mucinex OTC combination products

As OTC products, both Advil and Mucinex are available in fixed-combinations with different active ingredients into one dosage form.

Different Advil OTC combination products are:

  • 7-select Advil PM (Diphenhydramine + Ibuprofen)
  • Advil Allergy and Congestion Relief (Chlorphenamine + Ibuprofen + Phenylephrine)
  • Advil Allergy Sinus (Chlorphenamine + Ibuprofen + Pseudoephedrine)
  • Advil Back Pain (Ibuprofen + Methocarbamol)
  • Advil Cold & Flu (Diphenhydramine + Ibuprofen)
  • Advil Cold & Sinus Liqui-gels (Ibuprofen + Pseudoephedrine)
  • Advil Cold & Sinus PE (Ibuprofen + Phenylephrine)
  • Advil Cold and Sinus (Ibuprofen + Pseudoephedrine)
  • Advil Congestion Relief (Ibuprofen + Phenylephrine)

Different Mucinex OTC combination products are:

  • Childrens Mucinex Cold, Cough and Sore Throat (Acetaminophen + Dextromethorphan + Guaifenesin + Phenylephrine)
  • Mucinex D (Guaifenesin + Pseudoephedrine)
  • Mucinex DM (Dextromethorphan + Guaifenesin)
  • Mucinex Fast-max Cold and Sinus (Acetaminophen + Guaifenesin + Phenylephrine)
  • Mucinex Fast-max Cold, Flu and Sore Throat (Acetaminophen + Dextromethorphan + Guaifenesin + Phenylephrine)
  • Mucinex Multi-action Congestion, Stuffy Nose & Cough Liquid (Dextromethorphan + Guaifenesin + Phenylephrine)
  • Mucinex Multi-action Wet & Dry Cough Liquid (Dextromethorphan + Guaifenesin)
  • Mucinex Fast-max Severe Congestion and Cough (Dextromethorphan + Guaifenesin + Phenylephrine)
  • Mucinex Fast-max Day Time Severe Cold (Acetaminophen + Dextromethorphan + Diphenhydramine + Guaifenesin + Phenylephrine)

Can I take Advil and Mucinex together?

Advil OTC product that contains only ibuprofen as an active ingredient and Mucinex OTC products containing only guaifenesin as an active ingredient can be taken together safely because there is no direct interaction between these two drugs.

can you take ibuprofen with mucinex fast max

Can you take Advil cold and sinus and mucinex together?

Can I take Advil cold and sinus with Mucinex D together?

Advil Cold and Sinus is a combination of two active ingredients Ibuprofen + Pseudoephedrine while Mucinex D except guaifenesin also contains pseudoephedrine as active ingredients. Taking these 2 medicines together you will double the dose of pseudoephedrine, increasing the risk of side effects to happen. Side effects may include:

  • convulsions (seizures)
  • fast breathing
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • increase in blood pressure
  • irregular heartbeat (continuing)
  • shortness of breath or troubled breathing (severe or continuing)
  • slow or fast heartbeat (severe or continuing)
  • unusual nervousness, restlessness, or excitement

Thus Advil cold and sinus and Mucinex D should never be taken together.

Can I take Advil Congestion Relief and Mucinex Fast-max Cold and Sinus?

Since both products contains phenylephrine as an active ingredient, they should not be taken together, because their effects will become additive. If taken together they may increase the risk of side effect to happen. Side effects may include:

  • blurred vision
  • chest pain or discomfort
  • difficult or labored breathing
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • nausea or vomiting
  • nervousness
  • pain in the shoulders, arms, jaw, or neck
  • pounding in the ears
  • sweating
  • tightness in the chest
  • unusual tiredness

Thus you should avoid combination of these 2 medicines.

Can I take Advil Allergy Sinus and Mucinex Fast-max Day Time Severe Cold together?

Both medicines contains antihistamine drug in their preparation. Advil Allergy Sinus contains Chlorphenamine while Mucinex Fast-max Day Time Severe Cold contains Diphenhydramine. If these medicines are taken together their antihistamine effects will become additive and they will increase the chance of following side effects to happen:

  • sedation
  • drowsiness
  • sleepiness
  • dizziness
  • disturbed motor coordination
  • epigastric distress
  • thickening of bronchial secretions

Therefore, these 2 medicines should not be taken together

Patients with gastric or duodenal ulcers, gastritis, GERD, internal bleeding, patients who are on anticoagulant therapy (e.g. warfarin or heparin) should avoid these combination since they both contain NSAID drugs. Advil Allergy Sinus ibuprofen as an active ingredient while and Mucinex Fast-max Day Time Severe Cold contains acetaminophen. This combination should be avoided in such patients.

Can I take Advil PM and Mucinex Day Time Severe Cold together?

Both medicines contains antihistamine drug called diphenhydramine. If these medicines are taken together their antihistamine effects will become additive and they will increase the chance of following diphenhydramine side effects to happen:

  • drowsiness
  • sleepiness
  • sedation
  • disturbed motor coordination
  • dizziness
  • epigastric distress
  • thickening of bronchial secretions

Can you take mucinex and Nyquil at the same time?

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Alka-Seltzer – Ingredients, Benefits, Dosage, Side Effects and Interactions

May 23 2017 Published by under Medicines

What is Alka-Seltzer?

Alka-Seltzer is an antacid and pain reliever medicine, originally available in effervescent form that was first marketed by the Dr. Miles Medicine Company of Elkhart, Indiana, United States. It is available on the market as OTC product and used for relief of minor aches, inflammation, pains, fever, headache, stomachache, heartburn, indigestion, acid reflux and hangovers.

Alka-Seltzer is originally made of 3 active ingredients: aspirin (acetylsalicylic acid), sodium bicarbonate, and anhydrous citric acid. The aspirin works as a pain reliever, anti-pyretic and anti-inflammatory agent, whereas sodium bicarbonate and citric acid are antacids and work as stomach acid neutralizers due to their effervescent reaction with water.

There are several other Alka-Seltzer products on the market containing different combinations of active ingredients. Alka-Mints, A short-lived antacid non-aspirin form was introduced in 1994 and discontinued in 1997. Another non-aspirin-based variant, Alka-Seltzer Gold, was later released. From 1978 Alka-Seltzer is manufactures by Bayer Schering Pharma AG, Germany.

Is Alka Seltzer Plus good for heartburn?

What is Alka-Seltzer used for?

Different Alka-Seltzer products can be used for following symptoms:

  • Mild to moderate pain relieve including rheumatic and muscular pain, backache, nerve pain (neuralgia), migraine, headache, sprains and strains, toothache, sore throat, menstrual cramps.
  • Lowering a high temperature
  • Relieving symptoms of colds and flu
  • Cough relieve
  • Relieving symtoms of heartburn, indigestion and sour stomach
  • Allergy relief

What are different Alka-Seltzer products?

There are many different Alka-Seltzer products available on the market with different formulations such as:

  • Alka Seltzer Plus Cold & Flu Formula, Severe, Effervescent Tablets, Citrus, 20 tablets
  • Alka Seltzer Antacid/Analgesic, Effervescent Tablets, Original, 36 tablets
  • Alka Seltzer Plus Cold Formula, Multi-Symptom, Day/Night, Effervescent Tablets, 20 tablets
  • Alka Seltzer Cold Formula, Effervescent Tablets, Cherry Burst 20 tablets
  • Alka Seltzer Plus Cold Formula, Night, Lemon, Effervescent Tablets, 20 tablets
  • Alka Seltzer Calcium Carbonate/Antacid, Fruit Chews, 60 tablets
  • Alka-Seltzer Plus 20 ea
  • Alka Seltzer Plus Cold & Flu Formula, Multi-Symptom, Day/Night, Liquid Gels, 20 liquid gels
  • Alka-Seltzer Heartburn + Gas Reliefchews Tropical Punch, 32 Chewable Tablets
  • Alka Seltzer Calcium Carbonate/Antacid, Fruit Chews, Chewable Tablets, 36 tablets
  • Alka Seltzer Antacid/Analgesic, Effervescent Tablets, Lemon Lime, 36 tablets
  • Alka-Seltzer Heartburn + Gas Reliefchews Tropical Punch, 54 Chewable
  • Alka Seltzer Plus Cold Formula, Sparkling Original, Effervescent Tablets
  • Alka Seltzer Plus Cold & Cough Formula, Effervescent Tablets, Citrus
  • Alka Seltzer Antacid/Analgesic, Effervescent Tablets, Original
  • Alka Seltzer Antacid/Analgesic, Original, Effervescent Tablets
  • Alka Seltzer Cold Formula, Sparkling Original, Effervescent Tablets 20 tablets
  • Alka-Seltzer Severe Sinus Congestion & Cough, Day/Night, Capsules, Sinus Co-Pack
  • Alka-Seltzer Plus Day/Night Severe Cough, Mucus & Congestion Relief Liquid Gels, 20 Count
  • Alka Seltzer Plus Cold Formula, Effervescent Tablets, Orange Zest, 20 tablets
  • Alka-Seltzer Plus Honey Lemon Day Severe Cold + Flu Fast Multi-Symptom, Honey Leamon, 6 Packets

Alka-Seltzer original, plus, cold and cough, flu

Where can I buy Alka-Seltzer?

Alka-Seltzer is best sold in North and Central America including Caribbean as well in Australia and Asia-Pacific. In the 1980s and 1990s Bayer attempted to introduce the brand in Europe and South America with slight success, withdrawing them after a few years. As an OTC product it can be bought on the internet on different online-pharmacy websites.

What is Alka-Seltzer original?

Alka-Seltzer original is OTC product medicine in the form of effervescent tablet containing: Aspirin (325 Mg), Anhydrous Citric Acid (1000 Mg), and Sodium Bicarbonate (Heat-Treated) as an active ingredients.

It is used for the temporary relief of acid indigestion, heartburn and sour stomach accompanied with symptoms of headache or body aches and pains, toothache, upset stomach with headache from overindulgence in food or drink, menstrual cramps body aches and pain alone.

Original Alka Seltzer Antacid/Analgesic is available in effervescent tablet form and comes in a convenient 24 tablets box. This product is used for more than 74 years. It is manufactured in Mexico.

Follow next directions when using Alka-Seltzer original:

  • Place 2 tablets in 4 oz of water and dissolve tablets completely.
  • You do not needed to drink any of the rest that may be on the bottom of the glass.
  • Adults and children. Never exceed 8 tablets in 24 hours.
  • Adults 60 years and over should take 2 tablets every 4 hours or as directed by a doctor. They should never exceed 4 tablets in 24 hours.
  • Children under 12 years need to be consulted by a doctor when using Alka-Seltzer original

Is Alka-Seltzer original safe?

  • Children and teenagers who have or are convalescing from chicken pox or flu-like symptoms should never take this product. If children take this product, changes in behavior, nausea and vomiting occurrence should be followed, and parents should consult their child doctor because these symptoms could be an early sign of serious Reye’s syndrome
  • In some predisposed patients aspirin may cause severe allergic symptoms which may include: facial swelling, hives, asthma and even shock.
  • Alka-Seltzer original contains an NSAID, which may cause severe stomach bleeding. Patients who have bleeding problems should avoid this medicine. The chance of causing bleeding are much higher if you are age 60 or older, have had stomach ulcers or bleeding problems, or you take blood thinning anticoagulant medicines such as warfaring or steroid drug.
  • Patients should not take any other NSAIDs prescription or OTC drug (aspirin, ibuprofen, naproxen, or others) while they are using Alka-Seltzer original
  • Patients should not take 3 or more alcoholic drinks every day while using this product
  • Never more than prescribed or for a longer time than directed.
  • Do not use: if you are allergic to aspirin or any other pain reliever/fever reducer.
  • Patients should talk with their doctor if they have or had a history of stomach problems, such as heartburn or if they have high blood pressure, some heart disease, liver cirrhosis, or renal disease, or if they are taking a diuretic, you have asthma.
  • Patients should always ask their doctor or pharmacist before use if you are taking a prescription drug for diabetes, gout or arthritis.
  • Stop use Alka-Seltzer original if: an allergic reaction occurs and seek medical attention right after, or if you experience any of the following symptoms of stomach bleeding including: feel faint, have bloody or black stools, vomit blood, have stomach pain that does not get better, redness or swelling, pain gets worse or lasts more than 10 days, or if ringing in the ears or a loss of hearing occurs.

Is Alka-Seltzer safe during pregnancy and breast-feeding?

Alka-Seltzer original should be avoided during pregnancy and breast-feeding. It is especially essential not to take aspirin during the last 3 months of pregnancy except definitely directed to do so by a doctor because it may cause serious problems in the unborn child or complications during delivery. Alka-Seltzer original should also not be taken by breastfeeding mothers because aspirin may pass into breast milk and may harm nursing infant.

What is Alka-Seltzer plus cold and cough?

Alka-Seltzer plus cold and cough is OTC product medicine in the form of liquid-filled capsules containing: Acetaminophen 325 mg – fever reducer and mild pain reliever, Chlorpheniramine Maleate 2 mg – antihistamine drug with antiallergy and decongestive properties, Dextromethorphan Hydrobromide 10 mg – cough suppressant and Phenylephrine Hydrochloride 5 mg – antihistamine with decongestive properties as active ingredients.

It is used for the temporarily relieves the symptoms of the common cold. Alka-Seltzer Plus liquid-filled capsules are useful for relieving fever, nasal congestion, body aches, runny noses, and headache without the use of aspirin. They can be used both, on day or night.

Follow next directions when using Alka-Seltzer plus cold and cough:

  • Never take more than the recommended dose or as directed by the doctor.
  • Adults and children 12 years and over: take 2 capsules with water every 4 hours. Do not take more than 10 capsules in 24 hours or as directed by a doctor.
  • Children under 12 years: do not use.
  • Store at room temperature. Avoid excessive heat.
  • Do not use if blister is cut or broken.

Is Alka-Seltzer plus safe?

  • Alka-Seltzer plus contains acetaminophen. If this product is overdosed it can cause severe liver damage. This may occur if more than 12 capsules are taken in 24 hours, which is the maximum daily dose. During Alka-Seltzer use other products containing acetaminophen should be also avoided.
  • Avoid 3 or more alcoholic drinks every day while using this product.
  • Never use this product to sedate children.
  • Talk to your doctor if you have: liver disease, high blood pressure, thyroid disease, heart disease, diabetes, cough with excessive phlegm, glaucoma, a breathing problem such as emphysema or chronic bronchitis, difficulty with urination due to enlargement of the prostate gland, asthma, persistent or chronic cough such as occurs with smoking or emphysema.
  • Ask a doctor or if you are using the blood thinning drug such as warfarin, taking tranquilizers or sedatives.
  • Do not use during pregnancy or breast-feeding, and ask a health professional before use.
  • Keep out of reach of children.
  • In case of overdose, get medical help or contact a poison control center right away.

What is Alka-Seltzer Cold Formula?

Alka-Seltzer Cold formula is OTC product medicine in the form effervescent tablets containing: Aspirin 325 mg, Chlorpheniramine Maleate 2 mg, Phenylephrine Bitartrate 7.8 mg. It is used for quick relief of the sore throats, pain, fever and nasal congestion often related with the flu and colds.

The effervescent tables start to work almost immediately. Two sparkling original flavored tablets should be completely dissolved in water.  This medicine will provide you at least four hours of comfort.

Follow next directions when using Alka-Seltzer Cold formula:

  • Adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours.
  • Do not exceed 8 tablets in 24 hours or as directed by a doctor.
  • Children under 12 years: do not us

Adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 8 tablets in 24 hours or as directed by a doctor. Children under 12 years: do not us

What are Alka-Seltzer calcium carbonate/Antacid chewable tablets?

Alka Seltzer Calcium Carbonate Antacid chewable tablets are OTC product that provides quick and effective relief of heartburn, upset stomach and acid indigestion. Product contains antacid calcium carbonate in dose of 750 mg as an active ingredient. Each tablet is stuffed with a blast of fresh, fruit flavor. Chewable tablets are specially-designed with a quick-dissolving formula providing fast-acting relief.

Follow next directions when using Alka-Seltzer calcium carbonate/antacid chewable tablets:

  • Do not take more than 10 chewable tablets during a day.
  • Adults and children 12 years and over: chew and swallow 1-2 chewable tablets every 2 to 4 hours as symptoms occur, or as directed by a doctor.
  • Children under 12 years: consult a doctor for proper use

What are Alka-Seltzer Heartburn + Gas Relief chewable tablets?

Alka-Seltzer Heartburn + Gas Relief is OTC product in the form of chewable tablets containing antacid substance calcium carbonate in dose of 750 mg and simethicone 80 mg which is anti-flatulent/gas substance. It is used for the relief of: heartburn, gas, bloating, pressure in the stomach and upset stomach.

It should be used in following way or as directed by the doctor:

  • Adults and children 12 years and over: Chew and swallow 1-2 chewable tablets every 2 to 4 hours as symptoms occur, or as directed by a doctor.
  • Children under 12 years: Consult a doctor. Do not take more than 6 chewable tablets in a 24-hour period.

What is Alka-Seltzer Plus Flu?

Alka-Seltzer Plus Flu is OTC product with combination of 3 active ingredients: aspirin 500 mg, chlorpheniramine 2 mg and dextromethorphan 15 mg that is used for relieving flu-like symptoms such as: fever, dry cough, runny nose, nasal congestion.

It is available in the form of effervescent tablets. Adult’s dose is: 2 tablets fully dissolved in 4 oz of water on every 6-8 hours; not exceeding 8 tablets per day. Children younger than 12 years should not take this product unless doctor tells otherwise.

What is Alka-Seltzer PM?

Alka-Seltzer PM is a combination of an analgesic aspirin in dose of 500 mg and antihistamine drug diphenhydramine in dose of 38,3 mg. It is used for the temporarily relief of headache and aches, allowing easier fall asleep and better rest because of diphenhydramine sedative effects. It is available in the form of a caplet. Usual adult dose are 1 caplet on every 12 hours.

How to take Alka-Seltzer effervescent tablets?

  • Always take Alka-Seltzer effervescent tablets as directed by your doctor. Check the label on the product for proper dosing instructions.
  • Never remove the medicine from the package until you are ready to take it. Make sure that your hands are not wet when you open effervescent tablets.
  • Do not swallow or chew the tablets. Dissolve the tablet in a glass and add about 120 mL of cold water. Allow the tablet to dissolve completely and then drink it.
  • If you miss a dose of Alka-Seltzer effervescent tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Never take 2 doses at once.
  • Ask your doctor any questions you may have about how to use Alka-Seltzer effervescent tablets.

alka seltzer original vs extra strength

How Alka-Seltzer works in the body?

As described above, there are many Alka-Seltzer products with different formulation and combination of active ingredients. Active ingredients that can be found in Alka-Seltzer products are following: aspirin, chlorpheniramine, phenylephrine, acetaminophen, citric acid, sodium-bicarbonate, dextromethorphan, diphenhydramine and doxylamine.

Aspirin works as an irreversible inhibitor of both prostaglandin synthesis and platelet aggregation and it is stronger than other salicylic acid derivatives. This makes acetylsalicylic acid different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. As a result of prostaglandin synthesis inhibition analgesic, antipyretic, and anti-inflammatory effects are caused.

Chlorpheniramine works by blocking the muscle responses to histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle. It acts as histamine H1 antagonist and is used for relieving allergic reactions such as: rhinitis, hay fever, urticaria, and asthma.

Phenylephrine is a vasoconstrictor substance with decongestant properties that relieves symptoms resulting from upper respiratory tract irritation. It shrinks inflamed mucous membranes, decreases nasal congestion and tissue hyperemia. Phenylephrine is a sympathomimetic amine that works predominantly as agonist of α1 -adrenergic receptors. It also has some effects on beta adrenergic receptors.

Acetaminophen works by inhibiting pain impulse generation peripherally and may inhibit the production of prostaglandin in the CNS. It also reduces fever by inhibiting hypothalamic heat-regulating center.

Doxylamine is antihistamine drug that competitively blocks histamine from binding to H1 receptors. It has significant antimuscarinic activity and penetrates CNS, which may induce sedation.

Citric acid and sodium bicarbonate are antacids which neutralizes stomach acid

Dextromethorphan works as a cough suppressant with central effects on cough center in medulla.

Who should avoid taking Alka-Seltzer?

  • Patients who suffer from asthma should not take Alka-Saltzer products containing aspirin.
  • Patients with a history of gastrointestinal disorders
  • Patients with kidney or liver problems.
  • Patients with high blood pressure or heart disease or.
  • Patients taking anticoagulant therapy such as warfarin
  • Patients who are going to have or recently had surgery.
  • Patients who suffer from gout issues
  • Patients on a sodium-restricted diet.
  • Patients with an enzyme deficiency called G6PD deficiency.

Alka-Seltzer side effects

Alka-Seltzer may cause some of the following side effects:

  • Dysrhythmias
  • Hypotension
  • Tachycardia
  • Agitation
  • Cerebral edema
  • Coma
  • Confusion
  • Dizziness
  • Headache
  • Subdural or intracranial hemorrhage
  • Lethargy
  • Hives
  • Rashes
  • May potentiate peptic ulcer and cause stomach distress or heartburn
  • Dyspepsia
  • GI bleeding
  • Ulceration and perforation
  • Nausea
  • Vomiting
  • Prolonged prothrombin time
  • Palpitations
  • Sedation
  • Fatigue
  • Confusion
  • Depression
  • Tremors
  • Irritability
  • Insomnia
  • Euphoria
  • Hemolytic anemia
  • Thrombocytopenia
  • Agranulocytosis
  • Anorexia
  • Wheezing
  • Thickening of bronchial secretions
  • Restlessness
  • Headache
  • Hypertension
  • Severe peripheral and visceral vasoconstriction

Gastrointestinal issues such as nausea, vomiting, abdominal pain or diarrhea may be caused in some individuals. Such patients should take Alka-Seltzer with or after food.

Ulceration or bleeding in the GIT has been also described. Stop taking Alka-Seltzer and consult your healthcare provider immediately if you get any sign of bleeding from your stomach or bowels including: blood, passing black, tarry or bloodstained stools.

Some Alka-Seltzer preparations, especially those with acetaminophen may cause changes in liver function.

Increased time taken to stop bleeding has been also described after Alka-Seltzer administration.

Allergic reactions may also develop including: skin rashes, swelling of the tongue, lips and throat or narrowing of the airways. Angioedema and bronchospasm may also happen in some predisposed patients. Get immediate medical help if you think you’ve had an allergic reaction to Alka-Seltzer.

Can I take Alka-Seltzer with Advil?

Never take Alka-Seltzer with anti-inflammatory painkillers/ such as Advil because this increases the chance of getting side effects on the gut, such as ulcers, bleeding and abdominal issues because of the additive effects.

Can I take Alka-Seltzer with Tylenol?

Always consult your pharmacist or doctor if you are planning to take some of the Alka-Seltzer and Tylenol products together. Tyelnol contains acetaminophen as an active ingredient, and some Alka-Seitzer products (e.g. Alka-Seltzer Plus Severe Allergy Sinus Congestion & Headache, Alka-Seltzer Plus Night Cold Formula, Alka-Seltzer Plus) already contains acetaminophen, so if taken together with Tylenol, their effects will become additive, increasing the risk of side effects, including sever liver damage.

Also, both products may contain antihistamine or decongestive drugs and if taken together they may increase the risk of causing sedation or cardiovascular issues especially in predisposed patient with heart diseases.

Can I take Alka-Seltzer with Diclofenac or Naproxen?

Never take Alka-Seltzer with anti-inflammatory painkillers/ such as diclofenac or naproxen because this increases the chance of getting side effects on the gut, such as ulcers, bleeding and abdominal issues because of the additive effects.

Can I take Alka-Seltzer with Prednsione or any other corticosteroid?

Never take Alka-Seltzer with corticosteroids drugs such as Prednisone as they may increase the risk of ulceration or bleeding in your gastrointestinal tract.

Can I take Alka-Seltzer with Warfarin?

Alka-Seltzer products contain aspirin and thus they shouldn’t be taken with Warfarin, because of the additive anti-blood-clotting effect and increase risk of bleeding.

 Alka-Seltzer and Methotrexate interactions

Don’t take Alka-Seltzer with methotrexate, because it contains aspirin that can reduce the elimination of methotrexate from the body and increase its side effects. The two should not usually be used together, unless on the advice of a doctor.

Can patients with liver disease use Alka-Seltzer safely?

Some Alka-Seltzer products contain acetaminophen which is primarily metabolized in the liver to inactive forms. However, small amounts of the medicine are converted by minor pathways to metabolites that can cause hepatotoxicity or methemoglobinemia. Patients with hepatic impairment may be at increased risk of toxicity due to increased minor metabolic pathway activity.

Severe liver injury, including cases of acute liver failure resulting in liver transplant and death, has been reported in patients using acetaminophen. Therapy with acetaminophen should be administered cautiously in patients with hepatic insufficiency.

What is the drug metoprolol tartrate used for? Metoprolol: Uses, Dosage, Side Effects

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Metoprolol tartrate

May 22 2017 Published by under Medicines

What is Metoprolol tartrate?

Metoprolol is a special kind of β1 receptor blocker type medication which marketed under Lopressor. This is mostly used for chest pain, high blood pressure, abnormally fast heart rate. Metoprolol also uses to prevent serious headaches in those with migraines.

This is normally sold in formulations which can be given intravenously or taken by mouth directly. In 1969, metoprolol was made for the first time. As per the research in 2013, metoprolol was at no 19th in the list of most prescribed medication in the United States of America.

What is metoprolol tartrate 50 mg used for?

What is metoprolol used for?

Metoprolol is a special kind of drug or known as a beta blocker which affects blood circulation through arteries, veins and hearts. This is mostly used for the treatment of high blood pressure and chest pain which is also known as angina. Metoprolol is also preventing the heart attack.

What is metoprolol molecular formula and weight and drug class?

 metoprolol tartrate classification  metoprolol molecular formula

Chemical name: (RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol

Molecular formula: C15H25NO3

Weight: Average: 267.3639 Monoisotopic: 267.183443671

This compound belongs to the class of chemical entities known as tyrosols and derivatives. These are compounds containing a hydroxyethyl group attached to the C4 carbon of a phenol group. Metoprolol undergoes to a class of drug which is known as beta blockers and it better works for the treatment of chest pain, heart attack and high blood pressure.

How metoprolol works in the body?

As all of you know the heart is one of the vital organs of human body, which control all the blood push process through blood vessels to the needed parts. There are some receptors, known as beta adrenergic receptors in your heart which indicate the heart muscle to process the blood out of the heart and send around the body at the time of activated by hormones.

Beta blockers mostly attach to the beta receptors in the heart and discontinue the hormones which usually activate the receptors like as usual. As a result, the pump of the blood rate certainly goes down and this means the blood pressure will decrease when you will take this drug. This is a useful thing as it always helps to reduce the stress on the cardiovascular system and protect human from fatal stroke or heart attack.

Metoprolol brand names

Metoprolol is the active component of medication and sometimes called as the generic name. You can find several drug brand names in which you can find metoprolol as the active ingredient. So that’s the main reason behind the medication you are taking might be called differently like:

  • Lopresor
  • Toprol-XL
  • Betaloc
  • Minax
  • Metrol
  • Metohexal

You can get the metoprolol each of these above mentioned brand names and works in a similar way to the same thing in the human body. Simply, the brand name is different as they are made by various companies.

What is FDA approved indications for metoprolol?

Metoprolol is a special type of medication which is known as beta blocker especially uses for the treatment of heart problems and help blood circulation through veins and arteries. It is specially used to treat hypertension which is also known as high blood pressure and angina or chest pain. This medication is also used for the treatment of heart attack.

Metoprolol dosage forms and strengths

How long does it take for metoprolol tartrate to take effect?

Metoprolol is the best prescription medicine used to treat various conditions mostly involving blood vessels and heart such as angina, congestive heart failure and high blood pressure and it also heap people those who have the heart attack.

This medicine comes in the form of extended-release tablets or immediate-release tablets and mostly taken once or twice per day as per the doctor’s suggestion. Metoprolol tablets are well available in a variety of strengths.

You can find extended-release metoprolol tablets in numbers of strengths like:

  • Generic metoprolol succinate or Toprol-XL 25 mg
  • Generic metoprolol succinate or Toprol-XL 50mg
  • Generic metoprolol succinate or Toprol-XL 100 mg
  • Generic metoprolol succinate or Toprol-XL 200 mg

Immediate-release metoprolol come with two types like:

  • Generic metoprolol tartrate or Lopressor 50 mg
  • Generic metoprolol tartrate or Lopressor 100 mg

Metoprolol dosage for different indications

Adult dose for angina pectoris Prophylaxis:

The initial dose you can take 100 mg orally in one or two divided doses. You can maintain the dose 100 to 450mg per day.

For Hypertensions:

The usual adult initial dose is 100 mg orally in one or two divided doses. You can maintain the dose 100 to 450mg per day.

For supraventricular Tachycardia:

Initially, you can take 100 mg orally in one or two divided doses and you have to maintain the dose 100 to 450 mg per day.

For Angina pectoris:

The initial dose is 100 mg orally as previous but maintains the dose 100 to 400 mg per day.

For Myocardial infarction:

Generally, in this type of treatment, you can find two stages of treatment like early treatment and late treatment and the dose is different also.

Early treatment:

You have to take 3 bolus injections of 5 mg in every 2-minute interval. The patients who can tolerate the full IV dose of 15 mg, 50 mg every six hours should be initiated after the full IV dose of 15 minutes and continue up to 48 hours. You have to maintain 100 mg dose orally on daily basis.

Late treatment:

Orally you need to take 100 mg twice per day. If you are going through critical myocardial infarction or who can’t tolerate the early treatment phase or physician want to delay the therapy for any certain health issues should be started the metoprolol medication as soon as their health condition allows for the metoprolol treatment.

Adult dose for congestive Heart Failure:

At the initial stage, you have to take 25 mg once regularly for two weeks those who have NYHA class II heart failure and 2.5 mg once those who have serious heart failure. The maintenance dose should be double in every two weeks up to the highest dose level which is 200 mg.

If the patient face worsening of heart failure then you may treat with increased doses of diuretics or some cases you need the lower dose or discontinue treatment until the worsening heart failure well stabilized. Initially, the patient may face difficulties with titration but should not preclude but if the patient experience any kind of symptomatic bradycardia then you have to reduce the dose.

Pediatric dose of metoprolol for Hypertension:

For this, you have two sections one is for immediate release and other is extended release. Let’s discuss in brief.

Immediate release:

For 1 to 17 years old, the initial dose should be 1 to 2 mg/kg per day and you can take it with two divided doses. One more thing the dose should always be adjusted according to the response of the patient. The maximum dose is 6mg/kg per day.

Extended release:

For 6 to 16 years of age, the initial dose is 1mg/kg per day and you have to take it once orally never take more than 50mg once per day. The minimum average dose is always one-half of the 25 mg tablet. The maintenance dose should always be adjusted according to the patient’s blood pressure result.

Metoprolol highest dose

200 mg per day is the highest dose of metoprolol but you need to consult your doctor for the best dose for you. Never take any extra dose or if you miss your dose then don’t take it double to adjust it because by doing this you may mark severe side effects or overdose problems.

Metoprolol overdose

Metoprolol overdose may lead various side effects on your body like severe sinus bradycardia, heart failure, atrioventricular block, cardiac arrest, vomiting, cyanosis, occasionally and other symptoms like   

  • Sleepy or very drowsy
  • Consciousness changes
  • No pulse or blood pressure
  • Stopping of heart
  • Unconsciousness
  • Bluish color lips, palms, nail beds, skin and fingernails
  • Consciousness loss

So in such cases, you need to consult your doctor immediately.

Metoprolol side effects

If you are taking metoprolol then you may face several side effects so if you mark any side effects then you may require proper medical attention. Let’s first discuss some major side effects. In this category, you have to consult your doctor immediately.

More common:

  • Sweating
  • Confusion
  • Feel discomfort or chest pain
  • Faintness
  • Dizziness
  • Breath shortness
  • Weakness or tiredness

Less common type:

  • Unusual weight loss or gain
  • Breathing problems
  • Chest tightness
  • Headache
  • Fatigue extreme level, double vision, difficulty with speaking
  • Vision loss
  • Cough
  • Swelling arms, hands, legs or feet
  • Tension, pain, noisy breathing, slow speech
  • Memory loss for short term
  • Dilated neck veins

Rare type:

  • Light-colored stools
  • Fever
  • Dark color urine
  • Continues vomiting or severe nausea
  • Loss of appetite
  • Feel difficulty in moving
  • Skin itching, clay-colored stools, chills, rash, sore throat
  • Side or lower back pain
  • Unpleasant breath odor
  • Blood vomiting
  • Weakness, unusual bruising or bleeding
  • Muscle stiffness or pain

If overdose occurs then you may mark some of the following side effects in such case you have to consult your doctor immediately.

Overdose symptoms:

  • Sleepy or very drowsy
  • Consciousness changes
  • No pulse or blood pressure
  • Stopping of heart
  • Unconsciousness
  • Bluish color lips, palms, nail beds, skin and fingernails
  • Consciousness loss

Minor side effects:

Some side effects are not so harmful with metoprolol intake so you don’t need to consult your doctor if you mark these side effects on your body. These side effects will go away after the medicine is well adjusted with your body after some days. But it’s always better to discuss regarding your problems with your doctor. So here is the list of those minor side effects.

Less common:

  • Tiredness, sleeping trouble, stuffy nose
  • Trouble in concentrating
  • Runny nose, nightmares
  • Loss in sexual ability, loss of pleasure or interest
  • Passing gas
  • Pain in breastbone or below chest
  • Bloated
  • Full feeling, irritability, indigestion feeling
  • Discouragement, dry mouth, belching
  • Excess gas in intestines or stomach
  • Sensation of spinning
  • Sexual intercourse interest decrease
  • Feeling of constant movement of surrounding or self
  • Feeling empty or sad

Rare Type:

  • Severe sunburn
  • Thinning of hair or hair loss
  • Dry eyes
  • Continuing unexplained noise in the ear
  • Nervousness or fear
  • Pain on erection of penis
  • Hearing loss
  • Bone pain

These are various kinds of side effects may occur on your body so it’s always better to consult your doctor and take the suggestion for the best treatment.

 How to take metoprolol?

It’s recommended that take metoprolol every day at the same time. You can take metoprolol with food or after your meal. Remember one thing you have to take the medicine as directed by your doctor never take more or less. There may be changes required in your dose but it totally depends on how your body reacts and a doctor can change the dose as per your health condition.

You may feel some side effects so never neglect just consult your doctor and take suggestion regarding the dose and other diet plans. This medication never cures your high blood pressure but it can control it up to some extent.

It’s better to swallow the whole tablet with a glass of water never crush, break or chew it. This medication dose always varies and it’s totally depending on your health issue and your body resistance so always takes the dose as recommended by your doctor.

Metoprolol for arrhythmias

Metoprolol or beta blockers are always prescribed by the doctor in case of arrhythmias, not all time like after cardiac arrest the routine administration is always harmful and not recommended at all. But in the case of normal arrhythmias, you can take metoprolol and can get the better result. Always consult your doctor and take the suggestion for the best medication for your health.

Metoprolol for hypertension and angina pectoris

Metoprolol medication is always good and effective for both hypertension and angina pectoris. In the case of Hypertension, the usual adult dose for initial stage is 100 mg orally in one or two divided doses. You should maintain 100 to 450 mg every day. In the case of angina pectoris, the initial adult dose is 100mg orally same as Hypertension but you should maintain the dose 100 to 400 mg per day.

Metoprolol for myocardial infarction

Metoprolol works better for the myocardial infarction. At the early stage of treatment, you can take 5mg IV every two minutes 3 doses as tolerated. Full 50mg orally every 6 hours starting 15 minutes after the last IV dose and just continue for forty-eight hours is the patients tolerant of full IV dose.

In the case of intolerance of full IV dose,5 or 25mg orally and it’s depending upon the intolerance beginning 15 minutes after the last IV dose or when the clinical condition allows. For late treatment, you can maintain a dose which is 100mg orally twice per day. As per the study beta blockers for myocardial infarction should treat 1 to 3 year.

Metoprolol for heart failure

Metoprolol specially uses for heart problems like chest pain, high blood pressure. This medication always reduces the heart rate and slower down your high blood pressure so most of the doctor prescribe this medicine for heart diseases.

If you have serious heart block problems then you should take the low dose as per the doctor suggestion. 25mg metoprolol tablets once a day dose is the common adult dose for heart failure. The highest tolerated dose is up to 200mg orally once in a day.

Metoprolol for hyperthyroidism

At the time of chronic administration, the clearance of metoprolol or beta blockers are metabolized by the liver, as a result, it may be increased in the hyperthyroidism patient’s body because of the active blood enzyme. So it’s always better to consult your doctor for the perfect therapy and accurate dose. It normally differs according to the blood concentrations.

Metoprolol and Bronchospastic disease

Those who have bronchospastic disease can’t receive beta blockers because of its relative beta1 cardio selectivity but Metoprolol Succinate extended tables can be used for the patients with bronchospastic problem those who can’t tolerate any antihypertensive treatment. You can use low possible dose because beta 1-selectivity is not fully absolute.      

Metoprolol for Pheochromocytoma

If metoprolol tablets are used for Pheochromocytoma then you should use it with the combination of an alpha-blocker, and only after the initiation of alpha blocker. If you take it without alpha blocker then the blood pressure will increase due to the reduction of beta-mediated vasodilatation in skeletal muscle.     

Metoprolol for anxiety

In metoprolol, you can get the beta1 receptors so this medication is also recommended by doctors for social anxiety or other relevant anxiety disorder.

How long does it take for metoprolol to work?

Metoprolol normally works immediately but the full effects of this medicine take about two weeks to get free from dizziness and other side effects. So never stop take medicine suddenly if you feel any type of side effects without the suggestion of your diction.

Can you take metoprolol in the case of Major Surgery?

In the case of major surgery high dose is not allowed at all. Beta-blocking therapy should not be withdrawn earlier to major surgery, but the harm ability of the heart may augment the risk of surgical process or normal anesthesia.   

Can metoprolol cause a heart attack?

No, metoprolol never causes the heart attack because this medication uses for high blood pressure and prevent high blood pressure which normally the main cause of heart attack in most of the cases. As metoprolol uses for the treatment of chest pain and heart attacks there is no suck risk of heart attack by taking this medication.

Can metoprolol cause low blood pressure?

Metoprolol help to lower your blood pressure so if you take the too high dose then the blood pressure of your body may drop dangerously and you may feel light headedness, fainting and dizziness.

Do metoprolol make you feel tired?

Most of the people those who takes beta blockers have no side effects but Yes, in some cases you may feel tired if you are taking beta blockers as it slows down your heart.

Can diabetics take metoprolol?

Yes, diabetics can take metoprolol but it’s not recommended at all for high doses of beta-1 and you must take beta blockers cautiously as per the prescription of the doctor. Never take any decision without consulting your doctor otherwise you may face serious health issues.

Can I take metoprolol if I have asthma?

No, you can’t take metoprolol if you have serious asthma problem. If it is quite necessary to take metoprolol then beta-1 selectively is always considered as safer but always should be used with more caution. Just take the advice of your doctor and take the dose accordingly.    

Can I abrupt metoprolol therapy suddenly? Can metoprolol cause withdrawal effects?

No, you can’t abrupt metoprolol therapy suddenly or can’t discontinue the metoprolol therapy suddenly if you have artery disease. It’s always recommended that consult your doctor before taking any decision.

Metoprolol medication you can’t stop suddenly but the doctor may reduce the dose as per the requirement.  Yes, metoprolol can cause withdrawal effects so in case you feel any side effects like this then consult your doctor soon because you may need any change in your dose.

Precautions and warnings during metoprolol use

There are many warnings and precautions for the metoprolol use like

  • If you have allergy to metoprolol then you can’t use this medication.
  • Serious heart diseases like slow heart rate, sick sinus syndrome, heart block
  • If you have asthma, Sleep apnea, breathing disorder and COPD then consult your doctor before using this medication.
  • If you have low blood sugar then it may risky to use metoprolol
  • Liver disease person also can’t take high dose of metoprolol
  • Thyroid disorder
  • Raynaud’s syndrome
  • Tumor or adrenal gland problem patient

How long does metoprolol work?

Normally the half-life of metoprolol is around 3 to 7 hours but for the total elimination of metoprolol from the human system is around 5.5 times of the half-life that means around 38.5 hours.

How long does metoprolol stay in your system, urine, blood, saliva?

If you are taking metoprolol then it will stay at least 5 days in your system, urine, blood and saliva.

Metoprolol during pregnancy, Is it safe?

You can use this drug during pregnancy if you need it clearly. Unless outweighs, use of this medicine during pregnancy is not recommended at all. If you are using this during pregnancy then it should be lowest possible dose and also avoid 2 to 3 days to the expected delivery date. So, overall, it’s not safe but if it’s really needed then you can take low doses.

Metoprolol during breastfeeding

It’s quite low levels of metoprolol found in breastmilk and infant ingested very small amount which has no such adverse effects in breastfed infants. So it’s totally safe and there are no special precautions needed during breastfeeding.  

Can patients with renal disease take metoprolol safely?

Yes, renal disease patients can take metoprolol. The renal disease occurs because of high blood pressure. It’s quite important to keep your blood pressure in the normal range to avoid renal disease.

High blood pressure also damages the blood vessels and leading to hardening of the arteries. So it’s always needed to keep your blood pressure normal. Metoprolol normally works to lower down the blood pressure so it’s totally safe to use metoprolol those who have renal disease.

Can patients with liver disease take metoprolol safely?

Due to decreased drug clearance take metoprolol for patients with liver disease may be quite risky. Metoprolol therapy for liver disease patients should be always administered cautiously. Dose adjustment may be needed in such case so better to consult your doctor for the best suggestion.

Metoprolol absorption, metabolism and elimination

Metoprolol absorption is quite rapid and complete. As per the metabolism concern petoprolol metabolism is comprehensively hepatic via CYP2D6; significant first pass effect of ~50%. The half-life elimination of metoprolol for neonates is 5 to 10 hours and for adults, it is 3 to 4 hours. In the case of hepatic impairment or poor CYP2D6 metabolizer, then it is at least 7 to 9 hours.

Can I drink alcohol while taking metoprolol?

Metoprolol and alcohol together can be the cause of lowering your blood pressure, as a result, you may face various heal problems like dizziness, fainting, changes in heart rate and headache.

Normally these side effects can be seen at the very beginning of the treatment or increase of dose. So always discuss your problem with your doctors because maybe there is some adjustment of dose you need. Remember one thing never stop any medicine without the permission of the doctor.

Difference between metoprolol and propranolol

Both metoprolol and propranolol are known as cardiovascular medications which are also known as the beta blocker. Both medicines are helpful for anxiety. In the case of metoprolol you can find some side effects like Nausea, depression and shortness of breath and for propranolol, you may feel weight gain, withdrawal symptoms and insomnia.

There always a risk of interaction with alcohol in both of the cases. Both of the cases you need to follow the same food instruction either the empty stomach or after food choose anyone and continue that forever otherwise drug absorption may occur.

In the case of metoprolol, there is no certain method of use but for propranolol, there are four options like oral drops, pill and injection. Metoprolol specially taken for a Fib, Anxiety and High blood pressure and propranolol taken for migraines, panic attacks and anxiety. There is no such interaction between these two medications.

Difference between metoprolol and amlodipine

Amlodipine is a calcium channel blocker but metoprolol is a beta blocker or cardiovascular medication. Both medicines are helpful for high blood pressure. You may feel headaches, dizziness swelling by taking Amlodipine. In the case of metoprolo, you may feel Nausea, depression and shortness of breath and much more.

There may be the negative interaction between Amlodipine and alcohol and it’s same in the case of metoprolol and alcohol. For Amlodipine there are no certain food instructions but in metoprolol case, you should take medicine in a particular way for every time like with the food or on the empty stomach because if you take randomly then drug absorption may occur.

Amlodipine is mostly prescribed for high blood pressure but metoprolol is prescribed for many diseases like heart attack, high blood pressure, Palpitations, PVC’s and chest pain. There is no certain interaction between Amlodipine and metoprolol if you take it together but it’s always better to consult your doctor.     

Can I take metoprolol and amlodipine together?

Amlodipine and metoprolol may have preservative effects in lowering your heart rate or blood pressure. You may feel various health issues like dizziness, fainting, headache, unusual heart rate by taking these two medicines together. These problems may occur at the very beginning of your treatment or during the increase of dose so if you feel any problems then consult your doctor because you may need any dose adjustment.

Can I take metoprolol and verapamil together?

No, you can’t take metoprolol and verapamil together without the permission of your doctor as it may cause serious side effects on your body. If you take these two medicines together then you may face various health issues like weight gain, chest pain, swelling, fainting, headache and uncertain heartbeat.

If you are taking these medicines together and feeling any above-mentioned problems then consult your doctor there may be any dose adjustment for you.

Can I take metoprolol and aspirin together?

Somehow there is a minor interaction is available as per the medical science if you take metoprolol and aspirin together. This minor interaction can’t cause harm to human. It never requires any changes in any type of therapy also but it’s always depending on your doctor if there is any adjustment to your medicines for better treatment.

Can I take metoprolol and naproxen together?

If you are regularly taking metoprolol for your high blood pressure treatment then it’s better to consult your doctor for the use of these two medicines together. These two combinations of medicines may reduce the effect of metoprolol in lowering the blood pressure.

If you are frequently taking naproxen for your chronic pain or arthritis treatment then you have to consult your doctor for the dose adjustment. Don’t stop any medicine suddenly, consult your doctor and then take medicines accordingly.

Can I take metoprolol and Viagra together?

Yes, you can take metoprolol with Viagra because there is no such interactions occurs till the date as per the medical science but as per the safety concern, it’s always better to consult your doctor before taking these two medicines together.

 Can I take metoprolol and Advil together?

No, you can’t take metoprolol and Advil together without consulting to your doctor because if you take these two together then Advil may decrease the effect of metroprolol and you face many health difficulties so it’s mandatory to take the advice of the doctor and if he/she suggests then you can take.

Can I take metoprolol and Tylenol together?

Till the date, there is no interaction found in medical history so you can take metoprolol and Tylenol together but that doesn’t mean there is no interaction exist in all cases so it’s always recommended that take medicines after consulting your doctor.

Can I take metoprolol and lisinopril together?

You can take lisinopril and metoprolol together but sometimes it may lower your blood pressure and can be the cause of slow heart rate, as a result you may feel fainting, weakness, irregular heartbeat, loss of glucose in blood and many others.

If you feel any of these symptoms then consult your physician may be there is need a dose adjustment for you. Tell frankly about your all medicines and symptoms and one more thing never stop using any medicine without consulting your doctor.

Can I take metoprolol with water pills (diuretics) together?

It’s not recommended to take metoprolol with water pills if you have the serious heart condition like AV block or sick sinus syndrome or if you have slow heartbeats. If you are not able to urinate then don’t use this medicine. This combination of medicine normally uses for high blood pressure treatment. Never stop using medicine instantly if you feel fine so always better to consult your doctor and take the suggestion for the better dose.

Can patients with Congestive Heart Failure take metoprolol?

Congestive heart failure patients always need maximal medical treatment diuretics; digitalis and ACE inhibitor.Use of metoprolol may inhabit the activity of sympathetic and also help to reduce the risk of heart failure.

If you use metoprolol long term basis then you can find better improvement of left ventricular function and it also decreases mortality and reduce hospital readmission. So it’s mandatory to take metoprolol in low doses and require deliberate titration over weeks and months before patients can take maintenance doses.

Metoprolol + Hydrochlortiazide fixed combination

Metoprolol and Hydrochlorothiazide fixed combination of drug is never indicated for the initial stage therapy of Hypertension. If in any case the fixed combination is required as the dose for the need, then the fixed combination may be always more convenient than separate components.

Hydrochlorothiazide is contraindicated in patients with hypersensitivity or anuria but metoprolol is for cardiogenic shock, cardiac failure and sinus bradycardia.

Can I take metoprolol and digoxin together?

If you are taking digoxin and metroprolol together then it may slow down your heart rate and can cause many side effects on your body. You may feel various symptoms like vomiting, nausea, diarrhea, seizures; fatigue, abnormal heart beats, visual changes and much more so in such case contact your doctor.

For the safe use of these two medications together, it’s always better to consult your doctor there may be any changes required on the dose adjustment. Tell your doctors in details regarding all your medications.

Can I take metoprolol and hydralazine together?

Using Hydralazine and metoprolol together many slow your heart rate and lower your blood pressure. As a result, you may feel weakness, irregular heartbeats, dizziness or loss of glucose control.

So if you are taking these two medications together then it’s always better to tell your physicians regarding your unusual symptoms as there may be need of some changes in the dose of the medications. Never take or stop any medicine without consulting your doctor.

Can I take metoprolol and metformin together?

As there is no such known interaction between metoprolol and metformin till the date in medical records but however, there may be an interaction exist. So, it’s always recommended that never take any medications without consulting a physician for the safety of your life.

What should I do if I forget metoprolol dose?

It’s quite necessary to take the medication as soon as you remember it but if it is almost the time for the next dose then just skip that dose and try to continue your daily dosing as per your schedule. Remember one thing never take a double dose to adjust for the missed dose. It may put bad impact or side effects on your body. If in case you feel any type of uneasy then you can consult your doctor may be you need some dose adjustment.

All about storage and disposal of metoprolol medication

This medicine normally comes with a tightly closed container so always keep your medicine in it and make sure that the cover is tight enough so that the air could not pass through it. Always keep this medicine out of the reach of the children.

Always store this medicine at room temperature and away from excess moisture and heat. Never keep any medicine which is outdated just threw it away. Consult your physician to know the proper way of disposal of your medication.

What are the side effects of Triamterene HCTZ 37.5 25?

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Triamterene/Hydrochlorothiazide

May 20 2017 Published by under Medicines

What is triamterene/hydrochlorothiazide?

Triamterene/hydrochlorothiazide is known as a special drug combination which is known as diuretic or water pill. This is a combination of thiazide diuretic (hydrochlorothiazide) and potassium-sparing diuretic (triamterene). This combined medication works by making the elimination of sodium from kidney and water from your body as a result it can easily lower the blood pressure of your body. On the other hand the triamterene component always helps to minimize the loss of potassium.

What is Triamterene HCTZ 37.5 25 mg CP used for?

What are the molecular formula, class and weight of triamterene/hydrochlorothiazide?

 Molecular formula, class and weight of triamterene/hydrochlorothiazide

Triamterene belongs to the class of organic compounds known as pteridines and derivatives. These are polycyclic aromatic compounds containing a pteridine moiety, which consists of a pyrimidine fused to a pyrazine ring to form pyrimido(4,5-b)pyrazine.

hydrochlorothiazide belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position.

Molecular Formula: C19H19ClN10O4S2

Weight: 550.997g/mol

Triamterene/hydrochlorothiazide is a special class of drug which is known as a diuretic or known as the water pill. This is a useful medication which especially uses for the treatment of high blood pressure and edema.

How triamterene/hydrochlorothiazide works in the body?

You can use triamterene and hydrochlorothiazide combinations medication alone or with some other medicines and this combined medication always use for the treatment of water retention (edema) or hypertension also known as high blood pressure. If you have high blood pressure then it can be very dangerous for your health if you don’t take any medication for this problem as per your doctor’s prescription.

High blood pressure always put extra work load of the arteries and heart and if it continue for long term then your heart and arteries may not function properly as a result it can damage your blood vessels of the brain, kidney and heart. If this happened then there is always a risk of heart attack or kidney failure. If you can control your blood pressure then you are safer.

Both triamterence and hydrochlorothiazide are diuretic medicines or you can say water pills. The main work of this combined medication is to reduce the amount of water in the body by increasing the flow of urine which always helps to lower your blood pressure. The triamterene always helps to keep maintain the potassium level of your body rather absorbing too much salt. Always take this medication as per your doctor’s prescription.

Triamterene/hydrochlorothiazide brand names

Triamterene/hydrochlorothiazide is well available in two brand names like Dyazide, Maxzide. This medication is well available in two forms like tablets and capsules.

All of these medications work same and you will find the same active ingredients triamterene and hydrochlorothiazide in these drugs but the only difference is the name and sometimes price so don’t confused always follow your doctor’s prescription. All these medications are good for edema and high blood pressure.

triamterene hctz mechanism of action

What is triamterene/hydrochlorothiazide used for?

Triamterene/hydrochlorothiazide medication can use alone or with other medications to treat hypertension. High blood pressure always puts extra pressure on the heart and if it continuous for the long term then it can damage the blood vessels of kidney, heart, brain and can also increase the risk of heart failure or stroke. Triamterene/hydrochlorothiazide is also prescribed to treat edema.

Triamterene is a special type of water pill or diuretic which always helps to prevent your body from losing too much potassium. This combined medication always helps to reduce the amount of water in the body in your body and increasing the flow of urine which always help to reduce the high blood pressure.

Triamterene/hydrochlorothiazide dosage forms and strengths

Triamterene/hydrochlorothiazide medication is well available in two dosage forms like capsule and tablet. When the thing comes to strengths of this medication it is well available of three strengths like 50mg-75 mg, 25mg-37.5mg and25mg-50mg. Never take medication according to your own choice because it can cause serious damage to your health.  

Triamterene/hydrochlorothiazide dosage for different indications

As always, you need to remember one thing always that always takes medicines as per your prescription. Never take any extra dose or fewer doses because it can cause serious health problems for you. Here you can get some dose information regarding triamterene/hydrochlorothiazide dose for various indications. So let’s start.

Usual adult dose for edema:

The usual adult dose for edema is 25 to 50 mg of hydrochlorothiazide and 37.5 to 100 mg of triamterene orally single time per day. If the patient becomes hypokalemic on 50 mg of hydrochlorothiazide then you may be transferred directly to the hydrochlorothiazide 50 mg-triamterene 75 mg orally per day.

Patient who become hypokalemic on 25 mg of hydrochlorothiazide then you have to transferred the dose directly to 25mg hydrochlorothiazide and 37.5mg triamterene orally once per day. Patients in whom hypokalemia can’t be risked may be started with the dose 25 mg of hydrochlorothiazide and 37.5 mg of triamterene orally once per day.

Usual adult dose for hypertension:

The normal adult dose for hypertension patient is hydrochlorothiazide 25 to 50 mg-triamterene 37.5 to 100mg once per day orally. If the patient becomes hypokalemic on 50 mg of hydrochlorothiazide then you may be transferred directly to the hydrochlorothiazide 50 mg-triamterene 75 mg orally per day.

Patient who become hypokalemic on 25 mg of hydrochlorothiazide then you have to transferred the dose directly to 25mg hydrochlorothiazide and 37.5mg triamterene orally once per day. Patients in whom hypokalemia can’t be risked may be started with the dose 25 mg of hydrochlorothiazide and 37.5 mg of triamterene orally once per day.

Renal dose adjustment:

This is contraindicated in case of patients with acute, anuria and chronic renal insufficiency or significant renal impairment.

Liver dose adjustment:

If you have liver problem then you need to use this medication quite cautiously. Never use it as per your own decision always take advice from your physcian and use the medication as per the prescription for the better result.

Triamterene/hydrochlorothiazide highest dose

75 mg of hydrochlorothiazide and 100mg of triamterene combination is known as the highest dose of this medication. But for the highest dose, you need to check up your body and should ask your doctor.

Never take any excess dose because it may cause a serious health issue. So always take medication according to the prescription if you sill mark side effects then immediately check up your body because you may need the dose adjustment.    

Triamterene/ hydrochlorothiazide side effects  

If you are taking triamterene/ hydrochlorothiazide and you may mark some side effects then never neglect to any side effects, immediately go for the treatment. Sometimes you may need dose adjustment for the better result. If you have any signs of allergic reaction to triamterene/ hydrochlorothiazide then go for immediate health attention.

Major side effects

If you fell or mark any of the following side effects while taking triamterene/hydrochlorothiazide medication then immediately check with your doctor.

Incident not knows:

  • Abdominal or stomach pain
  • agitation
  • back or leg pains
  • black, tarry stools
  • bleeding gums
  • blisters, hives, or itching

Overdose symptoms

  • Face is warm or hot to touch
  • frequent urination
  • increased volume of pale, dilute urine
  • loss of strength or energy
  • pain or weakness in the hands or feet

Minor side effects

Sometimes triamterene/hydrochlorothiazide medication may cause minor side effects in such case there is no need of medical attention because this side effect will not stay a long time as it used to your body then these side effects may disappear but if side effects continue then you need to medical attention immediately.

Incident not known:

  • Decreased interest in sexual intercourse
  • feeling of constant movement of self or surroundings
  • inability to have or keep an erection
  • increased sensitivity of the skin to sunlight
  • loss in sexual ability, desire, drive, or performance
  • redness or other discoloration of the skin
  • sensation of spinning
  • severe sunburn
  • welts

How to take triamterene/hydrochlorothiazide?

Always take triamterene/hydrochlorothiazide medication as it was prescribed by your doctor for you. Never forget to follow all the directions on your prescription sheet. Don’t worry sometimes your doctor may change your dose for the better improvement of your health. Never use this medication in smaller or larger amounts or for the longer time than your doctor’s prescription because doing these things can be harmful to you.

Always take triamterene/hydrochlorothiazide orally with or without food. If you feel any type of stomach upset then take this medication with food to reduce the irritation of your stomach. This medication can increase the amount of urine or in other word, cause you urinate more often when you take this medicine at the starting so to avoid disturbing your sleep it’s always better to take your dose before 6PM.

In the case, you are using colestipol or cholestyramine then always ask your doctor how to take it with triamterene/hydrochlorothiazide medication never take it as per your own choice. If you have high blood pressure then you may feel tired for a week after starting the treatment but never stop medication even if you don’t feel better.

Is triamterene/hydrochlorothiazide addictive?

Yes, triamterene/hydrochlorothiazide can be addictive. As per the medical report only few people who take triamterene and hydrochlorothiazide. If you mark closely almost 4,767 people who have side effects to this medication.

Can triamterene/hydrochlorothiazide make you high?

No, there is no such indication still found. So triamterene/hydrochlorothiazide never makes you high but never stops this medication suddenly if any problem arises or any side effects occur.

Can I abrupt triamterene/hydrochlorothiazide therapy suddenly? 

No, normally you can’t abrupt triamterene/hydrochlorothiazide medication as per your own wish because it can be dangerous for you because if you have hypertension then abruption can cause a serious heart attack or heart failure which is always dangerous for you. Just go for medical attention and check up your body if you need abruption then you can abrupt it according to your physician instruction.

Can triamterene/hydrochlorothiazide cause withdrawal effects?

Yes, you may feel withdrawal effects if you are taking triamterene/hydrochlorothiazide medication. Most probably female those who are above 60 ages feel this effect. So if you are feeling withdrawal effect then immediately go for the treatment or some time you may need the dose adjustment. Never stop this medication suddenly by doing so can put bad effect on your body.

Precautions and warnings during triamterene/hydrochlorothiazide use

Here you can find some medical conditions which may interact with triamterene/hydrochlorothiazide so in such case it’s always better to go for medical help. This is very important part to know if you are using triamterene/hydrochlorothiazide medication. Never use this medication if you have urination problem, kidney disease or high potassium level in your blood.

If you are using any other diuretics then don’t use this medicine and never use low-sodium milk, potassium supplements because it can increase your blood potassium level to very critical condition so always aware of these things. You should be careful on some other things like:

  • If you are taking any herbal preparation, any prescription or non prescription medicines.
  • If you have any allergy to any foods, medicines and other substances.
  • If you are planning to become pregnant or you are pregnant or breast-feeding.
  • If you have heart, kidney, diabetes or liver problems
  • If you have unusual heart beat or kidney stones
  • If you are taking low salt diet
  • If you are taking any high blood pressure medication or digoxin

Some medicines also interact with triamterene/hydrochlorothiazide like

  • Potassium-sparing diuretics, potassium supplements, aldosterone blockers
  • Corticotrophin, corticosteroids, amphotericin b
  • Nonsteroidal anti-inflammatory medicines like indomethacin because these medications always decrease the effect of triamterene/hydrochlorothiazide.
  • Angiotensin-converting enzyme inhibitors because this type of medication always increase the risk of high blood potassium and kidney problems.
  • Digoxin, diazoxide
  • Anticoagulants or methenamine because triamterene/hydrochlorothiazide always decrease the effective of these two medications.

If you are using any above discussed medications or if you have any health issues as mentioned above list then never take triamterene/hydrochlorothiazide as per your own choice because it can be dangerous for you so in such case, always discuss all these things and take medication according to your physician’s prescription for the best result.

How long does triamterene/hydrochlorothiazide take to work?

Triamterene/hydrochlorothiazide medication takes around 24 to 48 hours to work but for the full benefit of this medication you have to wait for 5 to 7 days. For better information regarding this medication and dose information better ask your physician.

How long does triamterene/hydrochlorothiazide stay in your system, urine, blood, saliva?

This medication can take longer to completely out from your system like if you take this medication with food or you have certain medical conditions but normally the half-life of this drug is 7 to 15 hours so for the complete clear it may take around 23 to 30 hours to be completely out from your system, blood, urine and saliva.

Triamterene/hydrochlorothiazide during pregnancy

You can use this triamterene/hydrochlorothiazide drug during pregnancy only if the benefit outweighs the risk. There is no such controlled data in case of human pregnancy. Never take this medication according to your own choice during your pregnancy because it can be dangerous for you so always follow the doctor’s instruction for the better result.

Triamterene/hydrochlorothiazide during breastfeeding

There is no such clear-cut statement regarding use of triamterene/hydrochlorothiazide during breastfeeding but the decision should be made by your doctor and totally depends on your health condition.  Somehow it’s risky so it’s always better to ask your doctor about this and follow his/her instruction for the best result.

Can geriatric patients use triamterene/hydrochlorothiazide safely?

No, geriatric patients can’t use triamterene/hydrochlorothiazide safely if they have serious health issue because older persons can easily affected by side effects. Your doctor can suggest you the best dose according to your health condition so follow their instruction for the best result.

Triamterene/hydrochlorothiazide overdosage

In case of triamterene/hydrochlorothiazide overdose you need call your nearest poison help center and also contact for emergency medical attention. Overdose of triamterene/hydrochlorothiazide medication is always risky and can cause serious damage to your health so never take any extra dose.

You may feel various side effects on overdose of this medication like severe dizziness, nausea, weakness, fainting, fever and light-headedness. If you mark any type of side effects then immediately go for medical help.

What happens if I miss the dose of triamterene/hydrochlorothiazide?

Take the missed dose as soon as possible or when you remember. If it is almost the time for the next dose then just skip the dose and take care that never happen in future. Remember one thing never takes double dose or any extra dose for the drug adjustment because it can cause serious health problems to you.

Can I drink alcohol while taking triamterene/hydrochlorothiazide?

No, you can’t take triamterene/hydrochlorothiazide medication with alcohol because drinking alcohol can lower your blood pressure and you may mark many side effects of this medication so always try to avoid alcohol also try to avoid diet with high in salt. Always take medicines according to your prescriptions for the best result.

Can patients with liver disease take triamterene/hydrochlorothiazide safely?

No if you have serious liver disease then you can’t take triamterene/hydrochlorothiazide medicine safely. According to medical research if you have serious liver disease then triamterene/hydrochlorothiazide can put you on hepatic comma.

So in such case the patient should take this medicine more cautiously. You need to check up your health condition regularly as if you have liver disease like jaundice then the triamterene are normally metabolized by liver so in such case your doctor may reduce the dose for effective result.

Can patients with renal disease take triamterene/hydrochlorothiazide safely?

No, if you have the renal disease then you can’t take triamterene/hydrochlorothiazide safely because this medication can cause serious damage to your kidney vessel.

Sometime this medication is ineffective in case of renal function disorders if the glomerular filteration rate is low so thiazide diuretics therapy should be used with cautiously and some time your doctor may reduce the dose also. In the case of worst condition you have to discontinue this medication.

Triamterene/hydrochlorothiazide for arrhythmias

As per the medical science, report arrhythmias are found among those people who take triamterene/hydrochlorothiazide, especially who are female and above 60 years old. So it’s unsafe for the people those who have arrhythmias problems. Triamterene/hydrochlotothiazide can cause hyperkalemia, which may result serious arrhythmias. So use this medication cautiously.

Triamterene/hydrochlorothiazide for hypertension

Triamterene has the potassium-sparing property which always helps the hypertension patients. The frequent combination of hydrochlorothiazide and triamterene is always an effective medication for hypertension.

This medication inhabitants the epithelial sodium channel in the cortical duct and triamterene just reduces the potassium secretion which always reduces the risk of hypokalemia but there is no such clear report about whether triamterene/hydrochlorothiazide has any independent effect on blood pressure or not.

Triamterene/hydrochlorothiazide for heart diseases

Triamterene/hydrochlorothiazide is always safe for heart diseases because this drug normally treats high blood pressure and high blood pressure is always the cause of several heart diseases like strokes, heart attacks so it’s definitely prevents many heart diseases. In case of serious heart problem take this medication carefully if any side effects occur then immediately goes for health checkup or medical attention.

Triamterene/hydrochlorothiazide for congestive heart failure

Triamterene/hydrochlorothiazide oral diuretic is good for congestive heart failure and it’s quite effective at doses of 100 mg to 200 mg per day. It also never develops drug tolerance with long-term therapy. The only triamterene is not so effective so always very effective with hydrochlorothiazide.

Triamterene/hydrochlorothiazide for hyperthyroidism

According to the medical report, hyperthyroidism is found among people those who take triamterene/hydrochlorothiazide. Most of the female who are above 60 are affected by hyperthyroidism. So if you are one of them, then use it cautiously. Triamterene/hydrochlorothiazide may decrease the protein-bound iodine levels so the physician always aware of this thing during the prescription.

Triamterene/hydrochlorothiazide for anxiety

Yes, if you are taking triamterene/hydrochlorothiazide then you may have anxiety problem in future. As per the medical report, it is found that mostly female who are above sixty years old are affected by anxiety. So if you are taking this medication then be cautious about it because it can increase the anxiety problems.

Can triamterene/hydrochlorothiazide cause low blood pressure?

Yes, triamterene can cause low blood pressure and you may feel many side effects like fainting, weakness, tired. So if you mark any side effects during your triamterene medication then immediately go for medical checkup. Sometimes you may need dose adjustments or any other medications. Never take any medication according to your own choice or never stop this medication suddenly without medical attention.

Can diabetics take triamterene/hydrochlorothiazide?

No, you can’t take triamterene/hydrochlorothiazide if you have diabetes problem. Triamterene/hydrochlorothiazide may raise your blood sugar so in such case you need to monitor your sugar level on regular basis so if you can’t do that then it’s too risky to use this medication.

Due to problem in the rennin-angiotensin-aldosterone axis this medicine is not safe for the diabetics’ patients. If you are using then you need to monitor your blood sugar level and serum potassium level and renal function regularly for safety.

Triamterene/hydrochlorothiazide and acidosis

Acidosis normally alters the extracellular potassium and may lead rapid increase in serum potassium level and it can increase the effect of acidosis. Because of the hyperkalemic effects triamterene/hydrochlorothiazide should be avoided in patients. If you have serious problem then you need to check up your serum potassium and acid-base balance on regular intervals for the best dose of the medication.

Triamterene/hydrochlorothiazide and hyperkalemia

This is not safe to use triamterene/hydrochlorothiazide for hyperkalemia because this medication contraindicated the potassium serum concentration which can cause serious hyperkalemia problems as a result cardiac arrhythmias so in such situation, at the initial stage of therapy you need to check up your serum potassium on regular intervals and you may also need dose adjustment so do worry take medication according to your prescription.

Triamterene/hydrochlorothiazide and asthma

According to medical research, asthma is found on people those who are using triamterene/hydrochlorothiazide medication and this is normally found on female those who are above 60 years of old and have been taking this medication for one to six months. So if you have asthma problem then use it cautiously because it can increases the asthma effect.

Triamterene/hydrochlorothiazide and hyperlipidemia

Triamterene/hydrochlorothiazide may enhance the cholesterol and triglyceride levels. Still there is no confirmations about these effects are for dose related or not. If you have pre hyperlipidema then you need to do regular monitoring of your health condition during this therapy some time you have to adjust the dose according to the lipid-lowering regimen which is always important.

Can I take triamterene/hydrochlorothiazide and aspirin together?

As per the medical report till now there are no such interactions found between triamterene/hydrochlorothiazide and aspirin medications together but that doesn’t mean that there is no interactions exist so never take any medicines without the prescription. If you mark any side effects then go for a medical checkup because sometimes you may need dose adjustment for better improvement of your health condition.

Can I take triamterene/hydrochlorothiazide and metoprolol together?

According to the medical report triamterene/hydrochlorothiazide is not safe at all with metoprolol because this combination may lower your heart rate which can cause dizziness, weakness and other problems to you. It also can be the cause of irregular heartbeat, fainting and loss of blood glucose control. If you are using this medication then you need to checkup your blood pressure on regular basis.

Can I take triamterene/hydrochlorothiazide and esomeprazole together?

As per the medical science using esomeprazole with triamterene/hydrochlorothiazide can cause low blood magnesium which is also known as hypomagnesemia and if you will use it for long period of time then it can cause other problems like muscle spasm, heart rhythm, tremor and palpitations.

In case of children it can cause abnormal heart beat, upset stomach, fatigue and dizziness so for this you need to check up your body on regular interval and should take medicine as per the prescription of your physician.

Can I take triamterene/hydrochlorothiazide and duloxetine together?

According to medical test duloxetine with triamterene/hydrochlorothiazide medication can cause low blood sodium level which is also known as hyponatremia condition.

In such case you may mark various side effects like muscle spasm, nausea, weakness, irritability, memory impairment, confusion and in case of severe condition the patient may go to coma or fainting condition. So use this medicine cautiously and always check up your body and take medicine according to your prescription some time you may need dose adjustment also.

Can I take triamterene/hydrochlorothiazide and viagra together?

No, you can’t take triamterene/hydrochlorothiazide and viagra together. According to report there are drug interactions found between triamterene/hydrochlorothiazide and Viagra medication so never take these two medicines together.

Can I take triamterene/hydrochlorothiazide and metformin together?

No, you can’t take triamterene/hydrochlorothiazide and metformin together because according to the medical report drug interactions are reported people those who take metformin and triamterene/hydrochlorothiazide together. A doctor can only suggest you best medication according to your present health condition so never take medication according to your own choice because it can be dangerous for your health.

Can I take triamterene/hydrochlorothiazide and hydralazine together?

According to medical data base and research hydralazine and triamterene/hydrochlorothiazide medication together can cause serious interactions which can very dangerous for your health. So the answer is no, you can’t take it safely together without a prescription.

Can I take triamterene/hydrochlorothiazide and amlodipine together?

No, you can’t take triamterene/hydrochlorothiazide and amlodipine together because as per the medical research interactions found between these two medications so you should use it cautiously.

Can I take triamterene/hydrochlorothiazide and advil together?

No, you can’t take advil and triamterene/hydrochlorothiazide together without the instruction of your doctor. According to the research, these two medications can cause serious interaction so always harmful for human body.

All about proper storage and disposal of triamterene/hydrochlorothiazide medication

It’s always quite necessary to keep this medicine at a room temperature between 68 and 77 degrees F and avoid excess temperature, heat and moisture. Brief storage is permitted at temperature between 59 to 86 degrees F. Never keep this medication in your bathroom and always keep out of the reach of pets and children. To know the proper way of disposal you should ask your physician.

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Trazodone ‘’high’’

May 19 2017 Published by under Drug Abuse

What is Trazodone?

Trazodone is a Generic name for an antidepressant drug that is used to treat symptoms of depression. It belongs to the class of drugs known as serotonin modulators that works by affecting serotonin level in the brain. Trazodone has been shown to be effective for the treatment of major depressive disorders and other types of depressive disorders.

Studies showed that it is very useful in treating depressive disorders linked with insomnia and anxiety. This medicine does not exacerbate psychotic symptoms in patients with schizophrenia or psychosis disorders, thus it can be also used for this treating depressive symptoms in such patients.

This drug is available in the form of immediate-release and extended release oral tablets in doses of 50 mg, 75 mg, 100 mg, 150 mg and 300 mg. Common Brand names for trazodone are: Oleptro, Desyrel, Desyrel Dividose. In 1981, FDA first approved trazodone under the brand name Desyrel.

Can you get high off Trazodone 100mg

What is Trazodone used for?

FDA approved (label use) indications for trazodone are:

  • Alcohol Dependence
  • Anxiety
  • Insomnia
  • Major Depressive Disorder (MDD)

It is off-labeled used for following disorders:

  • Fibromyalgia
  • Complex regional pain syndrome
  • Control of nightmares
  • Panic disorder
  • Diabetic neuropathy
  • Bulimia nervosa
  • Obsessive-compulsive disorder (OCD)
  • Alcohol withdrawal
  • Schizophrenia as an adjunct to improve negative symptoms
  • Erectile dysfunction

How trazodone works in the body?

The exact mechanism of trazodone’s antidepressant action in man is still not fully understood. It is known that trazodone binds to serotonin’s 5-HT2 receptor selectively inhibiting serotonin uptake. At high doses it acts as a serotonin agonist while in low doses it acts as serotonin antagonist. When used for a long-term period, it may also affect postsynaptic neuronal receptor binding sites.

The overall sedative effect of trazodone is probably the result of the blockage of alpha-adrenergic receptors and modest histamine antagonism at H1 receptor. Trazodone dimly blocks presynaptic alpha2-adrenergic receptors and strongly inhibits postsynaptic alpha1 receptors. It has been also shown that trazodone does not affect the reuptake of norepinephrine or dopamine in the brain.

How does trazodone work in the brain?

Can Trazodone makes you ‘’high’’?

The FDA has no reported data that trazodone can cause euphoria, which is the experience that most drug-abusers want to achieve. But, since trazodone affects CNS, there is the potential for abuse or dependence similar after taking other antidepressants. While trazodone is not a usual drug of abuse, there have been reports that there are individuals who are using the drug recreationally.

Those who are taking Trazodone to get ‘’high’’ know that it will not give them euphoric high like other abused drugs, but sedative effects of the drug and various other types of cognitive impairment may be achieved.

Also, in order to get ‘’high’’ many drug abusers mix trazodone with alcohol, tranqulizers, or other drugs.  Alcohol can increase the effects of trazodone and make them additive.

Trazodone high may be exhibited if it is mixed with any barbiturates, or sedatives (e.g.Valium) but this is definitely not a thing to consider and do. Mixing of these substances can increase the severity and risk of side effects, elevating existing risks of side effects to happen, and making potentially life-threatening situation.

In patients who are suffering from major depressive disorders or other depressive disorders, the regulated and prescribed use of trazodone has been seen in many cases to lift the patient’s mood, and allow them to have normal life functioning.

For unregularly, recreational users of this drug there is very little indication that searching for a ‘’high’’  from this drug works in any way of use or form, indeed at best the crucial need to get sleep and calmed-down is all the vast majority will achieve.

Because trazodone may change the biochemistry of the CNS, it should never be consumed outside doctor prescription and recomendations.

What studies tell about Trazodone ‘’high’’ potential?

2 case-report studies from 1994 documented trazodone co-abuse with Prozac. It is believed to be the first actual documented case of co-abuse of trazodone. Another study from 1999 compared trazodone with Ambien and Halcion.

The results showed that that trazodone had a considerably less potential to be abused than the other two medicines, though, this can also be understood as that trazodone does have some potential to be abuse although it is most likely not commonly a primary drug of abuse.

It can be concluded that trazodone has a mild potential to be abused and for the development of a syndrome of physical dependence that is related with other antidepressant medications.

Trazodone ‘’high’’ experience

There are many reports on the Internet of those who were snorting trazodone in order to get ‘’high’’, indicating these people are taking the drug for nonmedical reasons. If snorted, trazodone will most possibly intensify some of its sedating effects, enhancing its onset of action, and causing a misuse of the medication for nonmedical reasons.

Here are some Trazodones ‘’high’’ experiences described on Erowid website (https://erowid.org/):

Case 1:

…At about 11pm I crushed a 50mg pill and split it into two lines, I decided to start off small so I snorted one line and saved the second one for later. As I did the first line I was surprised to find that the trazodone was virtually painless going up and gave my head a nice tingling sensation. I waited 15 minutes without noticing any change in perception so I decided to do the second line as well. I sat back down and began to chat online with my girlfriend. After about 45 minutes from taking the first line I noticed that colors became more defined and things began to move in a sort of slow motion. Objects became outlined and everything seemed to stand out. I got up to get a drink of water and my balance was about the same as it would be after getting drunk; I had a very hard time walking straight. At about this time my mood jumped; I became extremely happy and couldn’t stop smiling.  An hour after the first line was taken I began to get a pleasant body sensation that is somewhat comparable to a low dose of heroin and my body just pulsed with good feeling. I went to the bathroom to see how I looked and I saw that my eyes were red and my veins were bulging. At that point I checked my pulse and found that my heart was beating a little faster than usual, but nothing fast enough to be concerned about. After that I just sat on the couch very relaxed and watched tv for a while. I drifted off to sleep sometime after and woke up early the next morning feeling well rested and with a lot of energy. My lifted mood was very apparent the next day as well.

can you overdose on trazodone and die?

Case 2:

…I’ve tried several benzodiazepines (clonazepam and alprazolam), and also ambien (zolpidem) and while they usually sedate me in a pleasant way and allow me to get sleep, I find that I usually wake up the next day feeling less than refreshed, and I fear this is due to their negative effects on ‘sleep architecture’. I feel that I’ve been short on deep and satisfying sleep due to near daily stimulant use, so one night I attempted to deepen and enhance my sleep with trazodone 25mg. The drug was taken a half hour before bedtime with a snack (significantly enhances absorption). I was surprised to begin perceiving the effects after about 5 minutes. A heaviness in my limbs and a general feeling of physical satisfaction was noted. My arms and legs felt very good staying put and not moving. As the drug wore in I also noticed a bit of physical clumsiness and a tiny amount of mental slowness and disorientiation, which was a welcome change of pace from the frenetic daytime life of stimulants. I proceeded to go to bed 30 minutes after dosing. Lying in bed I felt like I could be comfortable not moving for hours – something I rarely if ever feel. I didn’t fall asleep straight away because I wasn’t used to the sort of spaced-out headspace that the trazodone was putting me in, but due to the fact that it removed all anxiety and because I was so physically comfortable, I enjoyed lying in bed for about a half hour until I fell asleep. My sleep was definitely enhanced. I woke up fewer times and fell back to sleep when I did wake. My body wasnt nearly as restless as it normally would be, and my dreams were intensely vivid and memorable. The next morning I felt the ‘trazodone hangover’ which consisted of continuing body buzz from the night before, and a bit of grogginess and physical slowness. The negative effects disappeared by lunchtime, however, but the great feeling of physical refreshedness persisted!! Trazodone provides me with a near constant physical ‘refreshed’ feeling of being comfortable in my body. Whether this is due to refreshing sleep or the effects of the drug I do not know. Either way I feel very healthy now and like my sleep has been restored. One side effect of using trazodone is that I feel a bit more carefree and have less anxiety than normal. I also do not know whether this is coming from the drug itself (25mg is a very small dose, however) or from the fact that I always feel refreshed and ready to go in the mornings. Trazodone is one of the safest sleep aids (in terms of dependency) and seems to be one of the most beneficial in terms of effects on sleep architecture and mood. I’d highly recommend it to people who feel like they cant get enough deep sleep or who deal with restless leg or middle of the night awakenings. Dont take too much – I believe if I had tried 100mg or above the disorientation and strange feeling would have been severe.

Trazodone addiction

Any patients who use antidepressant drugs such as trazodone for a period of longer than 6-8 weeks may possibly develop a physical dependence on this drug.  It is important to know that physical dependence does not necessarily indicate abuse or addiction.

Patients who take trazodone or same medications strictly for medicinal indication, in recommendable doses under their doctor supervision may develop a physical dependence, but they are not addicted and not considered as abusers them rendering to the formal clinical criteria for addiction and abuse as presented by the American Psychiatric Association.

According to the definition, addiction and abuse require the nonmedical (no-diagnosed) use of drugs that result in a number of negative events for the individual and lead to stress or functional impairments.

How to know if I someone is trazodone abuser or addict?

Signs that certain individual is abusing or become addictive to trazodone include:

  • The person has no indication for trazodone use and takes trazodone without a prescription.
  • A person has prescription for trazodone but it uses the drug more often or in higher doses than recommended or in the way the drug is not recommended to be taken such as snorting or he/she combines trazodone with other drugs or alcohol.
  • A person with a prescription tries to get more trazodone than initially prescribed by doctor, shopping, buying it illegally, stealing etc…
  • The person starts to spend more time thinking about the drug and attempting to get trazodone.
  • The person remains to take trazodone no matter its usage leads to negative events, such as problems at work, relationships or school issues, etc.
  • The person starts to ignore his/her major obligations at work, school, as parent etc., as a result of trazodone abuse
  • Trazodone abuser begins to have health issues.
  • Even he/she knows that drug can cause serious problems, abuser continue drug administration and even starts combining it with other drugs.
  • The person feels pleasure while taking trazodone
  • Person feels that needs higher doses in order to obtain same effects. This is known as drug tolerance
  • After drug discontinuation, the person begins to demonstrate issues with withdrawal symptoms when going without the drug

Who abuses trazodone the most?

According to the National Institute of Drug Abuse and numerous scholarly sources about addiction and abuse, trazodone and similar-drug abusers are most likely:

  • Pepople who take prescription medications for nonmedical reasons. They often combine trazodone with other drugs or alcohol.
  • Antidepressant medication abuse usually occur secondary mixed with other drugs of abuse as opposed to being a primary drug of abuse. Also, individuals who abuse trazodone are far more likely to also have histories of abusing other drugs or addiction to other drugs of abuse.

how many milligrams of trazodone is fatal

Trazodone withdrawal

Like any other drug that has effects on the brain, after abrupt discontinuation of trazodone, withdrawal symptoms may occur. Even though manufacturers do not warn about this potential of causing withdrawal symptoms, it can occur specifically in patients taking higher doses of trazodone for long-term period.

Withdrawal symptoms may also occur after patient’s non-compliance with the treatment regimen, particularly when doses of trazodone were missed for several days. Some patients may find these symptoms as a good reminder that they have missed some trazodone doses whereas others may experience intense advrse events and permanently stop taking the medication.

Abrupt discontinuation of trazodone, may lead to the following withdrawal symptoms:

  • Agitation
  • Anxiety
  • Confusion
  • Dizziness
  • Headache
  • Insomnia
  • Irritability

Usually, these withdrawal symptoms are not too intensive and long-term, thus they medical attention is not required. However, in some rare cases it is possible for patients to develop condition called severe discontinuation syndrome that can last for several weeks and cause significant side effects. Severe emotional or psychological disturbance are considered as more dangerous symptoms of trazodone withdrawal.

Patients who are exhibiting such extreme issues may need admission into a medical facility to manage the withdrawal and to prevent possible harm. Some patients may develop withdrawal symptoms such as mood swings, aggression and irritability. These symptoms may compromise the patient’s safety.

Those who are taking trazodone as a sleep aid, abrupt discontinuation can lead to an insomnia recurrence or even worsen the condition.

Patients should never discontinue trazodone on their own, without consulting their doctor first. Generally, doctor recommends that patients slowly stop off the drug, tapering the dose and frequency to a lower rate, before finally discontinuing it. There are some reports of patients experiencing withdrawal symptoms after gradually tapering off the drug.

What is trazodone highest dose?

The recommended adult dosage for trazodone is 150 mg once a day. The dosage may be increased by 50 mg every 4 or 3 days. The maximum allowable daily dose should not exceed 400 mg for outpatients, while hospitalized patients may take up to 600 mg daily. Pediatric dose is 25 to 50 mg per day and it can be increased to up to 150 mg daily. Any excessive intake beyond the maximum dosage may lead to an overdose.

Trazodone overdose

Trazodone overdose usually hits neurologic, respiratory, cardiovascular and gastrointestinal system. Trazodone overdose symptoms may include:

  • Vomiting. Trazodone affects GIT, thus vomiting and nausea may be caused
  • Drowsiness. Due to antihistamine effects trazodone may cause CNS depression. In overdose situations drowsiness will be potentiated and may lead to further alteration of the mental status. Severe Trazodone overdose may lead to a coma.
  • Priapism. This condition is known as prolonged penile erection even in the situations without sexual stimulation. It is a result of the trazodone’s antagonistic on the alpha adrenergic receptors that cause blood vessels vasodilatation. The prolonged vasodilatation increases blood flow leading to persistent erection. Priapism is usually painful and is considered as emergency conditions because of possible ischemia to the tissues. Similar occurrence may also occur in the clitoris of female patients.
  • Arrhythmias. Trazodone overdose may provoke arrhythmias, because in higher doses traozodne binds to the beta adrenergic receptors. The most common type of arrhythmias caused by trazodone overdose is premature ventricular contractions.
  • CNS depression. Trazodone overdose may also lead to respiratory depression. Shortness of breath and decreased respiratory rate are usually the first signals of respiratory depression.
  • Seizures. Increased brain activity that may provoke seizure attacks may be also experienced with Trazodone overdose.
  • Decreased white blood cell counts. Trazodone may also have the effects of decreasing the white blood cell count leading to possible infections.
  • Death. Death may occur from respiratory and CNS depression as well as cardiac failures.

How long trazodone stay in your system?

The elimination half-life time of Trazodone is estimated within the range of 5-9 hours. So, after discontinuation it’ll take around 7.3 hours to eliminate half of the dose from your body.  To completely eliminate Trazodone from your system, it’ll take an average of 1.67 days.

After ingestion trazodone is metabolized to the primary metabolite known as “m-chlorophenylpiperazine” which has an elimination half-life of 2.4 to 6.8 hours.  However, other metabolites of Trazodone have been shown to have an elimination half-life time of up to 13 hours.

Although trazodone will be excreted during 2 days, elimination of different metabolites could take nearly 3 days. Different factors may have an impact on complete excretion of trazodone metabolites; thus is unlikely to exceed 4 days.

Different factors may influence how long trazodone will stay in your system. These factors include: age, body mass, genetics, metabolic rate, liver function, co-administration of food or drugs, urinary pH, dosage and frequency of use.

Does trazodone show up on drug test?

Trazodone is not considered as controlled substance, thus you won’t be tested on its present, and routine/home standard drug tests can’t confirm trazodone presence. However, it is true that trazodone may give false positive results due to chemical similarity with controlled-substances.

A metabolite of trazodone called meta-chlorophenylpiperazine, can rarely cause false positive test results on drug screens for ecstasy and other amphetamines. This false positive result can happen especially at an initial drug screening.

However, if this happens, doctors are going to perform another more advanced and precise test in order to confirm this positive result. This second test is used to check fully for Trazodone. So, if you haven’t taken illegal or any other controlled drugs, you should not worry about anything. The test administrator will confirm your drug test is clean.

Due to structural similarity to some benzodiazepines it is debatable whether trazodone may cause false positive results on benzos. According to many experts Trazodone will not generally give a false positive of Benzodiazepines.

How many mg of cyclobenzaprine to overdose and die?
What happens when you take too much Ambien?

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Cyclobenzaprine ‘’high’’

May 18 2017 Published by under Drug Abuse

What is Cyclobenzaprine?

Cyclobenzaprine is a Generic name for muscle relaxant and a CNS depressant. Chemically it is very similar to the class of antidepressants drugs called tricyclic antidepressants. It has similar molecular structure to Amitriptyline, differing by only one double bond. It is used to relieve skeletal muscle spasms and related pain in acute musculoskeletal conditions.

It is most commonly available on the market under the Brand name Flexeril. Amrix, Fexmid and FusePaq Tabradol are also common brand names for cuclobenzaprine. This drug is available in the form of a tablet or extended-release capsule to be taken by mouth.

It is available in doses of 10 mg, 15 mg and 30 mg. Cyclobenzaprine was first approved by the FDA in 1977 under the brand name Flexeril, and is currently manufactured by PD-RX Pharmaceuticals.

Is the drug flexeril addictive?

What is Cyclobenzaprine used for?

FDA approved (label use) indication for Cyclobenzaprine is acute muscle spasms. It is used as a muscle relaxant to reduce pain and tenderness and improve mobility. It may also be used along with other drugs and treatments for tetanus. Cyclobenzaprine is off-labeled also used for the treatment of fibromyalgia

How Cyclobenzaprine works in the body?

Similarly to the other tricyclic antidepressants, cyclobenzaprine exhibit anticholinergic activity, norepinephrine potentiation, and reserpine antagonism.

Cyclobenzaprine has no direct action on the neuromuscular junction or the muscle but it can relieve muscle spasms via central action, possibly at the brain stem level. Cyclobenzaprine binds to the serotonin 5-HT receptor and is considered an antagonist of 5-HT2 receptors. It reduces tonus of the muscles by decreasing the activity of descending serotonergic neurons.

cyclobenzaprine 10mg

There are various anecdotal reports on the internet suggesting that some people abuse cyclobenzaprine in order to achieve narcotic-like “high”, because it can cause drowsiness. It is known that cyclobenzaprine can produce moderate to severe anticholinergic effects thus in higher doses it may disrupt the activity of certain neurotransmitters in your brain which can lead to cognitive impairment which are most abusers seeking for.

However, at higher doses, severe ataxia may be caused, a neurologic condition in which you lose control of your muscle movements.

The street name for Cyclobenzaprine or Flexeril is mellow yellow or cyclone. The DEA does not currently have Cyclobenzaprine scheduled as a controlled substance, although due to its sedating effects, the drug does have a slight potential for abuse. Abusers usually take Flexeril as a most available brand name of cyclobenzaprine.

They says that Flexeril make them to feel subjective high, usually characterized by feelings of sedation, relaxation, and mild euphoria. This mild euphoria effect may be the best reason why some people are abuse this drug. However, Flexeril is mostly abused in combination with other CNS depressants, such as:

  • Alcohol
  • Benzodiazepines
  • Barbiturates

Sometimes this drug is abused in combination with stimulants such as amphetamines or cocaine, because some abusers want to calm down the stimulant high.

According to reports, singer Whitney Houston had five drugs in her system when she committed suicide in 2012, one of which was cyclobenzaprine.

While cyclobenzaprine is generally safe when used as directed, its abuse can have many adverse effects.

Can you die from an overdose of cyclobenzaprine?

Who abuses cyclobenzaprine the most?

In past few years, cyclobenzaprine abuse is increasing, and this is mostly because DEA reclassified muscle relaxants containing carisoprodol to the Schedule IV Controlled Substances category in 2012 meaning that those who are caught illegally possessing this drug can earn heavy fines and/or prison sentences.

But, cyclobenzaprine is still not classified as controlled substances, thus doctors are freer to prescribe them. Also such drugs are more likely to be available illegally on the Internet.

The National Survey on Drug Abuse and Health described that over 12% of Americans ages between 18 to 24 years old abuses prescription drugs for non-medical purpose, and over 2 % have dependencies on such drugs.

However, the big majority of them, about 94%, did not buy their drugs from street dealers. 67 % obtained them from medicine cabinets owned by family and friends or through illegal Internet pharmacies. This pattern of getting the drug is no doubt similar for Flexeril abuse.

What are the side effects of Flexeril (cyclobenzaprine) abuse?

Flexeril may cause many physical and psychological side effects if it is abused, some of these side effects may become far worse when combining it with alcohol or other drugs. Potential side effects of Flexeril abuse include:

  • Nausea
  • Elevated heart rate
  • Excessive drowsiness
  • Dry mouth
  • Dizziness
  • Headache
  • Confusion
  • Impaired cognitive function
  • Physiological dependence

If taken together with alcohol, there is a high chance of increased risk and severity of side effects to happen. Dangerous side effects may occur, including:

  • Increased drowsiness and dizziness
  • Slowed, labored breathing
  • Memory loss
  • Poor motor skills and cognitive function
  • Abnormal behavior
  • Seizures
  • Increased risk of alcohol poisoning or Flexeril overdose

Cyclobenzaprine ‘’high’’ experience

Researchers from the DEA have found that the majority of Flexeril abusers are also using other illegal and/or prescription drugs together with it. Abusers often take cyclobenzaprine in order to enhance the effects of alcohol, benzodiazepines, barbiturates and narcotic. They also take cyclobenzaprine as a sleeping pill to achieve deep states of relaxation.

If taken in high doses, cyclobenzaprine can create the sensation that the user is floating out of his or her body. Some abusers have experienced hallucinations and euphoria while taking Flexeril, although the drug is not considered as “good a high” as some other drugs.

Here are some cyclobenzaprine ‘’high’’ experiences described on Erowid website (https://erowid.org/):

Case 1:

“…I asked her about the ‘valium’ she bought and if she’d sell me a couple. I bought two for two dollars. When I got home. I looked up the pills on the internet to find that they weren’t Valium, but were really Cyclobenzaprine. Oh well. I snorted one anyway. I very clearly remembering that it hurt so much. My nose was on fire after snorting it. But less than one second later, I felt the effects. I got really sleepy, kinda felt like I was moving really slow. Felt like I was talking like I was really stoned. My brother got home, I asked him if I was talking weird or moving weird and he said no. I sat down on the couch and talked to him a bit about whatever. I couldn’t get comfortable worth shit. I changed my position a thousand times. I just could NOT get comfortable at all. It was really frustrating. I felt really relaxed, yes, but I couldn’t just get into the right position. It felt like I almost felt perfectly relaxed, but no, there was just one little thing that would make it imperfect and it frustrated me so much. I was also feeling rather sleepy. My eyes felt like they were going to stay shut each time I blinked. I went ahead and went to my bed and slept for a good 4 or 5 hours. I had some really interesting dreams. That was the best part of this ‘high’. When I woke up, though, I was kinda groggy and still feeling it a very little bit… “

Case 2:

“I noticed Flexeril, my favorite non-entheogen, seems to have a quasi-bad rap. A while back I was having a problem with stress induced migraines interfering with my vision. A neurologist ascribed this to tension in my neck. I was given first a combo of Flexeril (10mg) and medrin (??). I had taken Flexeril before courtesy of my father for muscle strain from excessive strength training; but only once. Getting a script to Flexeril was a god send. I was floating. Nothing I had ever taken has come close to Flexeril in sheer muscle relaxation, wonderful for doing exercises similar to the san’ti posture in xing yi. I can do my standing chi gung for many times what I could take before and muscle tremors never happen (also energy in the body seemed to be more subtle and smooth in its flow, hard to describe. I also noticed that mentally it was easy to find one pointedness, in fact it was hard to avoid it, but enlightenment on Flexeril is a far cry from the truth). Soon however I had eaten my two bottles full and to fill the void my neurologist prescribed me neurontin and some sort of migraine nose spray. I touched neither. He also suggested I get botox in my neck to help the tension. I never called him again after that.

Give me Flexeril or give me death..

will cyclobenzaprine get me high

Cyclobenzaprine overdose

Drowsiness is the most common overdose indication of overdose. Irregular heartbeat is also vry common symptom of cyclobenzaprine overdose. Difficulty breathing and anziety often accompany the latter symptom.

Rare symptoms and signs of overdose may include:

  • Agitation
  • Slurred speech
  • Confusion
  • Dizziness
  • Nausea or vomiting
  • Hallucinations

Extremely rare overdose symptoms could include:

  • Heart attack
  • Seizures
  • Neuroleptic malignant syndrome: reaction to the drug characterized by fever, muscle rigidity, altered mental status and autonomic dysfunction

Cyclobenzaprine withdrawal

After abrupt discontinuation of cyclobenzaprine, you may experience certain adverse symptoms known as withdrawal syndrome. Cyclobenzaprine is only intended to be used for 2 weeks, but when certain individuals use it for years or abuse it in high doses frequently they are more likely to develop the syndrome.

Withdrawal symptoms after cyclobenzaprine long-term use are flu-like and may include: nausea, vomiting, difficulty sleeping, sweating and muscle ache. Withdrawal syndrome can be easy by slowly tapering off the doses of cyclobenzaprine.

How long does cyclobenzaprine stay in your system?

To determine how long cyclobenzaprine stays in your system after complete discontinuation, it’s important to consider cyclobenzaprine average elimination half-life time which is estimated to be 18 hours.  According to this, the drug will be eliminated from systemic circulation in around 4.13 days after final dose is taken.

But, it is always required to consider the fact that elimination half-life can range between 8 to 37 hours, because there is important interindividual variations in regards to excretion. So, those who are the fastest metabolizers of Flexeril’s, their elimination half-life time is expected to be 8 hours, so the full amount of drug is expected to be eliminated from the system in around 1.83 days.

On the other hand, those who are slowest metabolizers with elimination half-life of 37 hours, for them it may take 8.48 days to fully eliminate the drug from their body. In overall, elimination of cyclobenzaprine will take between 4 and 5 days after discontinuation.

Different factors may influence how long cyclobenzaprine will stay in your system. These factors include: age, body mass, genetics, metabolic rate, liver function, co-administration of food or drugs, urinary pH, dosage and frequency of use.

Does Flexeril (cyclobenzaprine) show up in drug tests?

Routine urine drug tests that can be easily performed can detect the presence of cyclobenzaprine. Cyclobenzaprine has elimination half-life time of approximately 18 hours, so it will probably stay active in your body for 90 hours.

Therefore, it will be detectable on drug tests for 3.75 days after the last dose is taken, but this time period may vary from person to person. This means that if certain individual has liver or a kidney issues, the drug may stay in their bodies longer.

How to know if someone is abusing cyclobenzaprine?

Following questions may help you to conclude if you or someone else is abusing cyclobenzaprine:

  • Have you been using cyclobenzaprine for more than 2 weeks?
  • Are you taking cyclobenzaprine without a doctor’s prescription?
  • Are you taking cyclobenzaprine in amounts greater than 60mg a day?
  • Do you take cyclobenzaprine and any other drugs in combination with it for non-medical reasons, for example, to relax or to get high?
  • Do you use cyclobenzaprine in combination with alcohol, marijuana, or CNS depressants?
  • Do you experience withdrawal symptoms when you stop using drugs?
  • Do you use cyclobenzaprine to come down after cocaine or other stimulants use, or in order to get to sleep?
  • Do you find it unbearable to go more than 1-2 days without taking cyclobenzaprine for non-medical reasons?
  • Have you tried on your own to quit using drugs but failed?
  • Do you feel guilty or ashamed about your use of drugs?
  • Do members of your family or your friends criticize you for your drug problems?
  • Do you feel that your use of drugs is beyond your control?

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Does Ibuprofen expire?

May 17 2017 Published by under Expired Medicines

What is Ibuprofen?

Ibuprofen is an anti-inflammatory drug that works by reducing hormones that are responsible for inflammation and pain in the body. Ibuprofen comes under the category of NSAIDs (Nonsteroidal anti-inflammatory drug).

Ibuprofen is mainly indicated in fever pain or inflammation associated with arthritis, menstrual cramps or minor injury. It is frequently used to treat a headache, toothache and back pain.

How does ibuprofen work to relieve pain?

Does Ibuprofen expire?

Every medicine has a specific expiry date, which is marked for a reason. It is printed on the box in order to protect you from damaging your body and to cause the awareness about the reduced effectiveness of medicine in the body after the expiry date.

Usually, Ibuprofen has a longer shelf life but it may degrade 5-10% every year after the expiry date. Manufacturers provide a particular expiry date on Ibuprofen and they do not guarantee any benefit after expiry. Once Ibuprofen is expired, it loses its potency and it becomes unfit for use.

Does expired Ibuprofen still work?

Any expired medicines usually do not produce any harmful effects after expiry date but the effectiveness and potency of a medicine may reduce over time. Expired Ibuprofen may still work post expiry.

Studies have shown that expired Ibuprofen works effectively even after many years of expiry without causing any dangerous effects. One should avoid very high doses of expired Ibuprofen as it may prove harmful inside your body and can result in stomach ulcers.

Is it safe to take ibuprofen after expiration date?

Can I take expired Ibuprofen?

Any expired medication should not be taken as it may cause serious ill effects but still if expired ibuprofen is used for minor headaches and pain, it may not prove harmful. Expired Ibuprofen loses its effectiveness and potency post expiry date, so if you are taking an expired ibuprofen, it may not produce any effects after the expiry date. No manufacturer guarantee desired potency after the expiry of Ibuprofen.

As per a study was done by USFDA, on large stockpiles of the drugs, more than 90% of drugs are found effective and fit for use, even after 15 years of the expiration date and Ibuprofen was one of them. Therefore, the expiry date should not necessarily consider as a point where the medicine becomes unsafe for use or no longer effective.

However, it was also stated that effectiveness of any medicine might reduce over a period of time. Proper storage condition can enhance the shelf life of a medicine like Ibuprofen, so one should store the medicine in a cool place like the refrigerator.

Placing a medicine above the washbasin of your bathroom is the worst place to store any medicine because it can get humid and wet in bathroom temperature and it can get expire even before its expiry date. A High-Kitchen shelf (not above the stove) is the best place to store a medicine.

Does expired Ibuprofen cause side effects?

Expired medicines should never administer without proper information but Ibuprofen stays safe even after years of expiry date as per US military sponsored trial. Where more than 100 OTC (over the counter) medicines (including Ibuprofen) are found effective even after 15 years of the expiry date.

So expired Ibuprofen may cause side effects similar to unexpired Ibuprofen such as upset stomach, headache, nausea, vomiting, dizziness, diarrhea, constipation, stomach ulcers or drowsiness may occur.

Can expired Ibuprofen make me sick?

Different formulations have different stability when it comes to medicines. A tablet may have a longer shelf life (up to 60 months) whereas a capsule formulation may have a much shorter shelf life (not more than 36 months).  The effect of medicine also depends upon its shelf life apart from active ingredients and an expired medicine can make you fall sick if it gets rancid.

Stability of Ibuprofen depends upon the impurities present in the medicine. An impurity cannot be more than a 10th of the percent of a single dose, as even a single impurity is considered toxic.

For an example, if you take two tablets of Ibuprofen (400 mg each), you should not ingest more than 0.4 mg of such impurity, as it can prove toxic inside your body. Therefore, there are strict limits given by FDA for every medicine that each manufacturer should comply and should stick within the given limits.

Such impurities also increase with the passage of time as a degradant (degraded product) and are sufficient to make you seriously ill. If you do not store Ibuprofen at appropriate storage conditions, these impurities may double and can increase the risk of damaging of medicine. You should check Ibuprofen boxes for proper storage and should store them at certain temperature and humidity.

A drug cannot be sold if it is degraded into harmful by-products, even after showing proper potency, solvency, desired effects and zero contamination by bacteria because the certain by-products (degraded products) can affect the patient negatively.

Certain pills that contain inert substances (inactive ingredients) degrade faster than the ones with the only active ingredient. Such degradation products are highly important in stability testing and it takes a lot of extensive research to test the effects of these degradation products.

 What will happen if I take expired Ibuprofen?

Normally, when you take an expired Ibuprofen, it does not cause any harm but it may not show the desired effect due to reduced potency over the period. However, if you have an Ibuprofen that is more than 15 years old, do not administer it as it may cause:

  • Stomach ulcers
  • Dizziness
  • Urinary tract infections
  • Urine with a foul smell.

If already taken then avoid any strenuous activity as it may result in heart attack within half an hour of the following activity.

What should I do with expired Ibuprofen?

An expired medicine should never be thrown away or discarded in bins. If you have some expired ibuprofen, you should read the medicine’s label and follow the disposal instructions that are given on the label.

The proper disposal of medicine is necessary and an important issue that reminds everyone to dispose outdated and expired medicines and get rid of unneeded medicines.

Here is the visual showing how to dispose of medicines:

how to dispose of expired ibuprofen

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