APO 10 MG pill – Drug class, street names, uses, strength, side effects, overdose, price

What is APO 10 MG pill?

APO 10 MG is an imprint on a pill identified as white in an elliptical/oval shape. The pill contains cetirizine hydrochloride as an active ingredient in the dose of 10 mg.

Cetirizine is an antihistamine drug used for relieving allergy symptoms such as sneezing, itching, watery eyes, runny nose or urticaria.  It is supplied by Apotex Corp.

  • Imprint: APO 10 MG
  • Strength: 10 mg
  • Color: White
  • Shape: Elliptical/Oval
  • Availability: Prescription and/or OTC
  • Drug Class: Antihistamines
  • Pregnancy Category: B – No proven risk in humans
  • CSA Schedule: Not a controlled drug
  • Labeler / Supplier: Apotex Corp.
  • Inactive Ingredients: lactose monohydrate, microcrystalline cellulose, corn starch, magnesium stearate, hypromelloses, polydextrose, polyethylene glycol 3350, titanium dioxide
What is the APO pill used for?
What is Apo 10 mg used for?

Other labelers and repackagers of cetirizine hydrochloride

  • Major Pharmaceuticals
  • Rugby Laboratories Inc.
  • A-S Medication Solutions, LLC (repackager)
  • Physicians Total Care Inc. (repackager)

Active ingredients of APO 10 MG pill and identification

An active ingredient of APO 10 MG pill is cetirizine hydrochloride. Cetirizine is an antihistamine drug that reduces the concentration of natural chemical histamine in the body.

Histamine can produce symptoms of sneezing, watery eyes, itching and runny nose. Cetirizine is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or a runny nose or to treat itching and swelling caused by hives.

It appears as a white, crystalline powder that is water soluble.

APO 10 MG pill chemistry

Cetirizine hydrochloride:

IUPAC name: 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid

Molecular formula: C21H25ClN2O3

Molecular weight: 388.888  g/mol

Molecular structure:APO 10 MG pill chemistry

Drug class: Cetirizine hydrochloride belongs to the class of organic molecules known as diphenylmethanes which contain a diphenylmethane moiety made of a methane wherein two hydrogen atoms are replaced by two phenyl groups.

APO 10 MG pill uses

APO 10 MG pills contain cetirizine which is a potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma.

Differently from many traditional antihistamines, cetirizine does not provoke drowsiness or anticholinergic side effects.

FDA approved indications are:

  • Chronic Idiopathic Urticaria
  • Perennial Allergic Rhinitis (PAR)
  • Pollen Allergy
  • Upper respiratory tract hypersensitivity reaction, site unspecified

Cetirizine Oral : Uses, Side Effects, Interactions, Pictures, Warnings

APO 10 MG pill legal status

Cetirizine hydrochloride is not a controlled substance. It is available via prescription or as an OTC drug.

APO 10 MG pills mechanism of action

Cetirizine hydrochloride work by competing with body histamine for binding at H1-receptors on the cell surface, which results in the suppression of histaminic edema, flare, and pruritus.

The low incidence of sedation caused by cetirizine may be attributed to the lower penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain.

APO 10 MG pill pharmacokinetics

Absorption and Distribution. APO 10 MG pills are rapidly absorbed after oral administration achieving a maximal concentration of approximately 1 hour. 

The mean plasma protein binding of cetirizine is approximately 93%, independent of concentration in the range of 25–1000 ng/mL.

Metabolism and excretion. APO 10 MG pills are metabolized to a limited amount by oxidative O-dealkylation to a metabolite with negligible antihistaminic activity.

The enzyme or enzymes responsible for such metabolic reaction have not been yet identified. It is predominately excreted via urine. The mean elimination half-life time is 8.3 hours.

APO 10 MG pill use during pregnancy and breastfeeding

APO 10 MG pills should not be used during pregnancy unless the benefit outweighs the risk. It is classified in a B2 class by the US FDA pregnancy list of drugs meaning that animal models have failed to reveal evidence of teratogenicity and harmful effects on pregnancy, embryofetal development, parturition, and/or postnatal development, but there are no controlled data in human pregnancy.

Small and occasional doses of cetirizine would probably not cause any problems during breastfeeding. However, larger doses and long-term use may cause drowsiness and other adverse effects in the infant or decrease the milk supply.

The British Society for Allergy and Clinical Immunology recommends cetirizine use in its lowest dose as a preferred choice if an antihistamine is required during breastfeeding.

What are different brand names for cetirizine?

Different brand names for cetirizine are: All Day Allergy, All Day Allergy Children’s, Aller-Tec, Aller-Tec Children’s, Alleroff, Children’s Allergy Relief, Children’s Zyrtec, Equate Allergy Relief, PediaCare Children’s 24-Hour Allergy, Zyrtec, Zyrtec Hives

APO 10 MG pills side effects

Cetirizine hydrochloride may cause following side effects:

Common side effects:

  • Dizziness
  • Drowsiness
  • Tired feeling
  • Dry mouth
  • Sore throat
  • Cough
  • Nausea
  • Constipation
  • Headache

Serious side effects:

  • Fast, pounding, or uneven heartbeat
  • Weakness, tremors, or sleep problems
  • Severe restless feeling, hyperactivity
  • Confusion
  • Problems with vision
  • Urinating less than usual or not at all

How long APO 10 MG pill stays in the system?

Cetirizine 10 mg should be fully eliminated from the system in 24-hours.

APO 10 MG pill precautions and  warnings

  • Before taking APO 10 MG pills tell your doctor or pharmacist if you are allergic to it. Tell also if you are allergic to hydroxyzine; or to levocetirizine; or if you have any other allergies.
  • Pills may contain inactive ingredients, which can provoke allergic reactions or other problems. Talk to your pharmacist for more details.
  • Before using APO 10 MG pills, tell your healthcare provider or pharmacist about your medical history, especially if you had or have: difficulty urinating (such as due to an enlarged prostate), some kidney disease or liver disease.
  • If you are using APO 10 MG pills to treat hives, tell your healthcare provider if you have any of other symptoms because they may be signs of a more serious condition: hives that are an unusual color or hives that look bruised or blistered or hives that do not itch.
  • APO 10 MG pill may make you drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.
  • Avoid alcoholic beverages while using APO 10 MG pills.
  • Before having surgery, tell your healthcare provider or dentist if you are using these pills.
  • During pregnancy, APO 10 MG pills should be used only when clearly needed. Discuss the risks and benefits with your doctor.
  • APO 10 MG pills pass into breast milk. Consult your healthcare provider before breast-feeding.

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